Cov khoom

BBS4 yog ib qho ntawm ntau cov proteins uas nws qhov tsis xws luag ua rau Bardet-Biedl Syndrome (BBS), ntau lub cev tsis zoo, tshwm sim nrog kev rog rog.BBS4 polymorphisms tau cuam tshuam nrog kev rog uas tsis yog-syndromic morbid.BBS4 rog rog molecular mechanisms, thiab lub luag hauj lwm ntawm BBS4 noob nyob rau hauv adipocytes txawv thiab muaj nuj nqi tsis paub tag nrho.Tam sim no peb pom tias Bbs4 ua lub luag haujlwm ncaj qha thiab tseem ceeb hauv kev loj hlob thiab adipogenesis: silencing ntawm Bbs4 hauv 3T3F442A preadipocytes induced accelerated cell division thiab aberrant differentiation, pom tseeb los ntawm kev tshawb fawb morphologic (lub teeb, scanning thiab kis electron microscopy), metabolic tsom xam (fat). fatty acid profile thiab lipolysis) thiab adipogenic cov ntawv sau tseg (Cebpα, Pparγ, aP2, ADRP, Perilipin).Thoob plaws hauv adipogenesis thiab thaum muaj kev sib tw nrog cov rog, Bbs4 silenced hlwb tsim cov triglycerides ntau dua li kev tswj cov adipocytes, txawm tias me me (tseem ntau dua) cov tee uas muaj cov roj fatty acid hloov pauv.Yog li, cov rog ntau dua nyob rau hauv cov hlwb silenced yog qhov tshwm sim ntawm ob qho tib si tus nqi siab dua ntawm adipocyte proliferation thiab kev sib txawv ntawm qhov tsis sib xws ua rau augmented aberrant tsub zuj zuj ntawm cov roj ib lub cell.Peb qhov kev tshawb pom qhia tias BBS kev rog tuaj yeem yog ib feem vim yog lub luag haujlwm ncaj qha ntawm BBS4 hauv kev siv lub cev thiab cov txheej txheem pathophysiological uas cuam tshuam txog kev tsim cov nqaij adipose cuam tshuam rau kev rog.