Guanosine-5′-diphosphate, disodium ntsev Cas: 7415-69-2 Dawb hmoov 98%
| Catalog Number | xwm 90756 |
| Khoom npe | Guanosine-5'-diphosphate, disodium ntsev |
| CAS | 7415-69-2 |
| Molecular Formula | C10H13N5Na2O11P2 |
| Molecular Luj | 487.16 ib |
| Cov ntaub ntawv khaws cia | -15 rau -20 ° C |
| Harmonized tariff Code | 293499 0 |
Khoom Specification
| Qhov tshwm sim | Dawb hmoov |
| Assay | > 99% |
| Dej | <10% |
RasGrf1 thiab RasGrf2 yog homologous mammalian guanine nucleotide pauv yam uas muaj peev xwm ua kom muaj Ras lossis Rho GTPases.Cov noob RasGrf yog qhov tshwj xeeb tshaj tawm hauv lub hauv nruab nrab lub paj hlwb, txawm hais tias kev qhia tshwj xeeb ntawm ob qho chaw kuj tseem tuaj yeem tshwm sim rau lwm qhov.RasGrf1 yog paternally-expressed, imprinted noob uas qhia tsuas yog tom qab yug me nyuam.Hauv qhov sib piv, RasGrf2 tsis yog imprinted thiab qhia tau hais tias tus qauv dav dua.Ntau hom isoforms rau ob lub noob kuj tseem tuaj yeem kuaj tau hauv cov ntsiab lus sib txawv ntawm tes.RasGrf proteins nthuav tawm cov qauv qauv tsim los ntawm ntau qhov chaw suav nrog CDC25H thiab DHPH motifs lub luag haujlwm rau kev txhawb nqa GDP / GTP pauv, feem, ntawm Ras lossis Rho GTPase cov hom phiaj.Cov ntau yam tseem ceeb yog qhov tseem ceeb los txheeb xyuas lawv cov kev sib pauv hauv nruab nrab thiab hloov kho qhov tshwj xeeb ntawm lawv cov haujlwm ua haujlwm txhawm rau txuas cov cim sib txawv ntawm cov dej ntws mus rau ntau lub hom phiaj hauv qab thiab cov lus teb ntawm tes.Txawm hais tias lawv homology, RasGrf1 thiab RasGrf2 tso saib txawv lub hom phiaj tshwj xeeb thiab tsis sib tshooj ua haujlwm nyob rau hauv ntau yam kev taw qhia cov ntsiab lus ntsig txog kev loj hlob ntawm tes thiab kev sib txawv nrog rau cov neuronal excitability thiab cov lus teb lossis synaptic plasticity.Whereas ob RasGrfs yog activatable los ntawm glutamate receptors, G-protein-coupled receptors los yog hloov nyob rau hauv intracellular calcium concentration, tsuas yog RasGrf1 tau tshaj tawm kom tau txais los ntawm LPA, cAMP, los yog agonist-activated Trk thiab cannabinoid receptors.Kev soj ntsuam ntawm ntau yam kab mob nas kis tau pom qhov kev ua haujlwm tshwj xeeb ntawm RasGrf1 hauv cov txheej txheem ntawm kev nco thiab kev kawm, photoreception, tswj kev loj hlob tom qab yug menyuam thiab lub cev loj thiab pancreatic β-cell muaj nuj nqi thiab cov piam thaj homeostasis.Rau RasGrf2, lub luag haujlwm tshwj xeeb hauv lymphocyte proliferation, T-cell signaling teb thiab lymphomagenesis tau piav qhia.
