Deoxyribonucleic acids, ntses phev Cas: 100403-24-5
| Catalog Number | xwm 90579 |
| Khoom npe | Deoxyribonucleic acids, ntses phev |
| CAS | 100403-24-5 |
| Molecular Formula | - |
| Molecular Luj | - |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 293499 0 |
Khoom Specification
| Qhov tshwm sim | Dawb hmoov |
| Assay | 99% |
Pathogenic molecular pathways nyob rau hauv daim siab mob siab xws li kab mob siab C (HCV), autoimmune kab mob siab (AIH) thiab thawj biliary cirrhosis (PBC) tsis zoo.Kev sib txawv ntawm cov noob caj noob ces feem ntau tseem ceeb hauv cov kab mob pathogenesis.Kev Tiv Thaiv Kev Tawm Tsam Kev Sib Tham (SSH) yog ib txoj hauv kev genome-wide uas ua rau muaj txiaj ntsig zoo rau kev sib txawv ntawm mRNA transcripts.Peb tsom los ua cov kev soj ntsuam tshiab ntawm qhov sib txawv ntawm cov noob qhia nyob rau hauv cirrhosis siv SSH ua ke nrog ntau lub sij hawm rov qab transcriptase polymerase saw cov tshuaj tiv thaiv (RT-PCR).Daim siab transcriptomes hauv HCV cirrhosis, AIH cirrhosis, PBC, thiab cov ntaub so ntswg uas tsis muaj mob tau kuaj los ntawm SSH.Qhov tshwm sim ntxiv DNA (cDNA) clones tau rov kuaj dua rau qhov kev qhia sib txawv los ntawm dot-blot hybridization thiab tom qab ntawd ua ntu zus.Xaiv cov noob qhia tau ntsuas los ntawm lub sijhawm RT-PCR.Ua raws li SSH, 694 clones tau rov kuaj dua rau qhov sib txawv ntawm cov noob qhia, ntawm 145 tau ua tiav thiab pom tau los ntawm 89 cov noob sib txawv.Xya clones yog homologous nkaus xwb nrog qhia ib ntus tag (EST) sequences encoding noob uas tsis paub ua haujlwm.Up-regulated qhia ntawm plaub noob tau lees paub los ntawm real-time RT-PCR: transmembrane 4 superfamily tswv cuab 3 (tetraspanin CO-029) nyob rau hauv tag nrho cov hom ntawm cirrhosis, hedgehog interacting protein (HIP) nyob rau hauv AIH cirrhosis thiab chitinase 3-zoo li-1. (HC gp-39 lossis ykl-40) thiab arginine-glutamic acid rov (RERE) hauv HCV cirrhosis.RERE gene polymorphisms thiab splice variants tau pom nyob rau hauv tag nrho cov ntaub so ntswg kuaj.Tetraspanin CO-029 up-regulation feem ntau yog nyob rau hauv cov kua tsib ductular hlwb.Hauv kev xaus, kev soj ntsuam tshiab ntawm qhov sib txawv ntawm cov noob qhia nyob rau hauv tib neeg cirrhosis tau siv SSH ua thawj qhov kev tshawb pom.Tshwj xeeb, kev tshawb fawb ntxiv ntawm RERE gene thiab nws cov khoom hauv HCV kab mob siab tau lees paub.
