Cov khoom

Kev kho cov kab mob mammalian nrog cov tshuaj chemotherapeutic tuaj yeem ua rau muaj kev cuam tshuam ntawm cov pas dej nucleotide.Kev soj ntsuam cov kev cuam tshuam no hauv cov kab mob qog nqaij hlav los ntawm tib neeg cov peev txheej yog qhov muaj txiaj ntsig zoo rau kev ntsuam xyuas cov txiaj ntsig ntawm kev kho tshuaj thiab kev nkag siab zoo ntawm cov txheej txheem ntawm kev ua ntawm cov tshuaj no.Nyob rau hauv txoj kev tshawb no, peb chav kawm ntawm chemotherapeutic tshuaj nrog txawv mechanisms ntawm kev txiav txim tau siv nyob rau hauv txoj kev loj hlob ntawm cov tshuaj kho cell qauv.LC-based tsom metabolomics tsom xam ntawm nucleotides hauv cov hlwb ntawm pawg tswj hwm thiab pawg tshuaj kho tau ua tiav.Ntau cov ntaub ntawv ua cov txheej txheem tau muab tso ua ke rau kev txheeb xyuas cov peev txheej biomarkers cuam tshuam nrog kev ua ntawm cov tshuaj, suav nrog ib txoj hauv kev tsom xam ntawm qhov sib txawv, kev tsom xam cov ntsiab lus tseem ceeb, thiab cov neeg txais kev ua haujlwm cov yam ntxwv nkhaus.Intriguingly, cov qog hlwb ntawm ob pawg tswj hwm thiab pab pawg kho mob tuaj yeem paub qhov txawv ntawm ib leeg, thiab ntau qhov sib txawv tau lees paub tias yog potentia l biomarkers, xws li ATP, GMP, thiab UDP rau cov tshuaj antimetabolite, ATP, GMP, thiab CTP. rau DNA-damaging agents, as well as GMP, ATP, UDP, and GDP for the mitotic spindle agents.Ntxiv validation ntawm lub peev xwm biomarkers tau ua los ntawm kev siv tus txais kev khiav hauj lwm cov yam ntxwv nkhaus.Xav txog lawv qhov chaw sib raug zoo nyob rau hauv qhov nkhaus, uas loj dua 0.9, nws tuaj yeem xaus lus tias GMP thiab ATP yog qhov zoo tshaj plaws biomarkers rau DNA-kev puas tsuaj rau cov tshuaj, nrog rau GMP, ATP, thiab UDP rau ob chav kawm ntawm cov tshuaj.Qhov kev txwv nucleotide no tsis tuaj yeem paub qhov txawv ntawm cov tshuaj ntawm cuaj cov tshuaj, tab sis nws muab cov ntaub ntawv pov thawj ua ntej rau lub luag haujlwm ntawm pharmacometabolomics hauv kev txhim kho preclinical ntawm cov tshuaj tsawg kawg.