DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) CAS: 28718-90-3 99% Yellow hmoov
| Catalog Number | xwm 90505 |
| Khoom npe | DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) |
| CAS | 28718-90-3 |
| Molecular Formula | C16H15N5 · 2HCl |
| Molecular Luj | 350.25 Nws |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 2933998090 ib |
Khoom Specification
| Qhov tshwm sim | Cov hmoov daj |
| Assay | 99% min |
| Kev tshawb fawb siv nkaus xwb, tsis yog siv rau tib neeg | Kev tshawb fawb siv nkaus xwb, tsis yog siv rau tib neeg |
Melatonin koom nrog ntau lub zog ntawm lub cev, thiab nws muaj qhov sib txawv ntawm apoptosis hauv cov hlwb thiab qog nqaij hlav.Txawm li cas los xij, cov txheej txheem ntawm nws txoj haujlwm antitumor tsis nkag siab zoo.Hauv txoj kev tshawb no, peb pom tias melatonin txhim kho tunicamycin-induced apoptosis hauv tib neeg lub mis carcinoma MDA-MB-231 hlwb.Melatonin up-regulates pro-apoptotic protein Bim qhia ntawm qib transcriptional nyob rau hauv lub xub ntiag ntawm tunicamycin.Melatonin inhibits tunicamycin-induced COX-2 qhia hauv MDA-MB-231 hlwb.Tsis tas li ntawd, inhibition ntawm COX-2 kev ua haujlwm siv COX-2 inhibitor, NS398, nce tunicamycin-induced apoptosis.Interestingly, cov teebmeem no tsis cuam tshuam nrog melatonin receptor teeb liab txoj hauv kev.Pertussis toxin (ib qho Gi protein inhibitor) lossis luzindole (ib qho tsis tshwj xeeb melatonin receptor antagonist) tsis thim rov qab cov nyhuv ntawm melatonin.Tsis tas li ntawd, melatonin thaiv tunicamycin-induced NF-κB kev ua haujlwm, p65 nuclear translocation, thiab p38 MAPK ua ivation.Melatonin-mediated p38 MAPK inhibition pab txo qis COX-2 mRNA stability.Ua ke, peb cov txiaj ntsig tau qhia tias melatonin txhim kho kev ua haujlwm ntawm cov qog nqaij hlav los ntawm kev tswj hwm ntawm Bim qhia thiab txo qis ntawm COX-2 qhia hauv tunicamycin-kho MDA-MB-231 hlwb.
