Cov khoom

Txhawm rau kom paub meej cov txheej txheem pib ntawm dentin mineralization, cov nyhuv inhibitory ntawm 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) ntawm dentin mineralization tau tshawb xyuas.Cov nas tsuag (100 g) tau txhaj tshuaj subcutaneously nrog HEBP (8 mg P / kg) rau 7 lossis 14 d, thiab cov incisors tau ua tiav rau Ca histochemistry thiab / lossis electron microscopy.HEBP-kho incisors tau pom cov ntaiv zoo li lwm kab ntawm cov ntxhia pob zeb thiab cov pob zeb uas tsis yog-mineralized ntawm qhov kawg ntawm apical.GBHA tau nthuav tawm cov kev cuam tshuam nruab nrab ntawm Ca hauv cov khoom siv tsis yog-mineralized circumpulpal dentin matrix qhov twg electron microscopy qhia cov nplua nuj faib ntawm cov khoom zoo li electron-dense.Non-mineralized mantle dentin matrix yog qhov tsis zoo rau Ca tab sis muaj ntau lub matrix vesicles (MVs) uas muaj cov crystalline thiab / lossis amorphous mineral deposits.Mineralization ntawm circumpulpal dentin tshwm sim ntawm nws tus kheej ntawm MV-nplua nuj mantle dentin txheej hauv cov qauv cuam tshuam.Peb cov ntaub ntawv muab pov thawj histochemical ntawm qhov ua tau Ca-binding cuab yeej ntawm circumpulpal dentin matrix thiab nws tsis nyob hauv mantle dentin qhov twg MV-mediated mineralization tshwm sim.Nyob rau hauv lub mantle dentin, HEBP tsis cuam tshuam nrog kev loj hlob siv lead ua hauv MVs tab sis inhibits nws qhov kev loj hlob tom qab membrane rupture.Nws tau npaj siab tias circumpulpal dentin matrix muaj peev xwm ua kom tsis muaj zog ntawm MV-mediated mineralization ntawm mantle dentin, txawm tias MVs txiav txim siab qhov chaw pib thiab lub sijhawm ntawm dentin mineralization.