Cov khoom

Mucoadhesive films uas muaj curcumin-loaded nanoparticles tau tsim, aiming kom ntev lub sij hawm nyob rau hauv cov tshuaj nyob rau hauv lub qhov ncauj kab noj hniav thiab ua rau kom cov tshuaj nqus los ntawm lub buccal mucosa.Cov yeeb yaj kiab tau npaj los ntawm txoj kev casting tom qab kev koom ua ke ntawm curcumin-loaded chitosan-coated polycaprolactone nanoparticles rau hauv plasticized chitosan daws.Sib txawv molar pawg ntawm mucoadhesive polysaccharide chitosan thiab cov concentrations ntawm plasticizer glycerol tau siv los ua kom zoo rau kev npaj.Cov yeeb yaj kiab tau siv nruab nrab thiab siab molar pawg chitosan tau pom tias muaj homogeneous thiab hloov tau.Curcumin-loaded nanoparticles tau sib npaug ntawm cov yeeb yaj kiab saum npoo, raws li muaj pov thawj los ntawm atomic force microscopy thiab high-resolution field-emission gun scanning electron microscopy (FEG-SEM) dluab.Kev soj ntsuam ntawm cov ntu ntu ntawm zaj duab xis siv FEG-SEM qhia pom tias muaj cov nanoparticles hauv cov yeeb yaj kiab.Tsis tas li ntawd, cov yeeb yaj kiab tau ua pov thawj tias muaj qhov zoo ntawm cov dej hauv cov kua qaub hauv cov kua qaub, ua kom pom qhov o ntawm ib ncig ntawm 80% thiab hauv vitro ntev-tswj kev xa khoom ntawm curcumin.Cov txiaj ntsig no qhia tau hais tias cov yeeb yaj kiab mucoadhesive uas muaj nanoparticles muab txoj hauv kev zoo rau kev xa tawm ntawm curcumin, uas tej zaum yuav muaj txiaj ntsig tshwj xeeb hauv kev kho cov kab mob hauv lub cev uas xav tau kev xa tshuaj mus ntev.© 2014 Wiley Periodicals, Inc. thiab American Pharmacists Association.