D-Mannitol Cas: 69-65-8 96-101.5% Dawb crystalline hmoov
| Catalog Number | xwm 90226 |
| Khoom npe | D-Mannitol |
| CAS | 69-65-8 |
| Molecular Formula | C6H14O6 |
| Molecular Luj | 182.1718 Nws |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 29054300 ib |
Khoom Specification
| Melting Point | 164-169 Deg C |
| Qib | BP |
| Kev sib hloov tshwj xeeb | +23 - +25 |
| AS | <1 ppm |
| Poob rau ziab | <0.3% |
| Sulfate | <0.01% |
| Assay | 96 - 101.5% |
| Nickel | ≤ 1ppm |
| Acid | <0.2ml |
| Txo Qab Zib | ≤ 0.1% |
| Kev coj ua | Qhov siab tshaj plaws yog 20 us / cm |
| Cl | <0.007% |
| Qhov tshwm sim | Dawb crystalline hmoov |
Txhawm rau tshawb xyuas lub luag haujlwm ntawm oxidative stress thiab/lossis mitochondrial impairment nyob rau hauv qhov tshwm sim ntawm mob raum raug mob (AKI) thaum lub sij hawm sepsis, peb tsim ib tug sepsis-induced nyob rau hauv vitro qauv siv proximal tubular epithelial hlwb raug rau ib tug kab mob endotoxin (lipopolysaccharide, LPS).Qhov kev tshawb nrhiav no tau muab cov yam ntxwv tseem ceeb ntawm kev sib raug zoo ntawm oxidative stress thiab mitochondrial respiratory chain activity defects.Kev kho LPS ua rau muaj kev nce ntxiv hauv kev qhia ntawm inducible nitric oxide synthase (iNOS) thiab NADPH oxidase 4 (NOX-4), qhia txog cytosolic overexpression ntawm nitric oxide thiab superoxide anion, thawj hom reactive nitrogen (RNS) thiab reactive oxygen hom. (ROS).Lub xeev oxidant no zoo li cuam tshuam mitochondrial oxidative phosphorylation los ntawm kev txo cytochrome c oxidase kev ua haujlwm.Raws li qhov tshwm sim, kev cuam tshuam hauv kev thauj khoom hluav taws xob thiab cov proton siv thoob plaws mitochondrial inner membrane tshwm sim, ua rau txo qis ntawm mitochond rial membrane peev xwm, tso tawm ntawm apoptotic-inducing yam thiab depletion ntawm adenosine triphosphate.Interestingly, tom qab raug tsom los ntawm RNS thiab ROS, mitochondria tau dhau los ua tus tsim tawm ntawm ROS, yog li ua rau muaj kev ua haujlwm ntawm mitochondrial.Lub luag haujlwm ntawm oxidants nyob rau hauv mitochondrial dysfunction tau raug lees paub ntxiv los ntawm kev siv iNOS inhibitors lossis antioxidants uas khaws cia cytochrome c oxidase kev ua haujlwm thiab tiv thaiv mitochondrial membrane muaj peev xwm dissipation.Cov txiaj ntsig no qhia tias sepsis-induced AKI yuav tsum tsis yog tsuas yog suav tias yog qhov tsis ua haujlwm ntawm lub zog tab sis kuj yog cov lus teb ua ke, suav nrog cov xwm txheej hloov pauv, ROS teeb liab, kev ua haujlwm mitochondrial thiab metabolic orientation xws li apoptosis.
