Cov khoom

Cov kab mob hauv plab hnyuv metabolite ntawm ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol (compound K), tau raug tshaj tawm tias ua rau apoptosis hauv ntau hom qog noj ntshav.Txawm li cas los xij, cov txheej txheem raug tsim los ntawm kev sib xyaw K hauv tib neeg cov kab mob hepatocellular carcinoma (HCC) cov hlwb tseem tsis meej.Txhawm rau tshuaj xyuas cov txheej txheem apoptotic, peb tau tshawb xyuas cov nyhuv anticancer ntawm compound K hauv MHCC97-H.MTT kev soj ntsuam tau pom tias cov khoom sib xyaw K inhibited kev loj hlob ntawm MHCC97-H hlwb nrog cov tshuaj toxicity tsawg hauv cov kab mob hepatoma.Kev loj hlob ntawm lub voj voog ntawm tes thiab cov xov tooj ntawm tes tau pom qhov nce ntawm apoptotic sub-G1 feem.Kev kho mob ntawm MHCC97-H nrog compound K kuj ua rau txo qis hauv mitochondrial membrane muaj peev xwm (Δψm) thiab DNA puas.Kev tshawb fawb ntxiv tau pom tias cov tshuaj K upregulated Fas, FasL, Bax / Bcl-2 ratio thiab downregulated pro-caspase-9, pro-caspase-3 nyob rau hauv ib koob tshuaj-nyob ntawm seb, thiab nws kuj inhibited Akt phosphorylation.Cov txiaj ntsig no qhia tau tias cov khoom sib xyaw K ua rau muaj kev cuam tshuam cov cell proliferation thiab induces apoptosis hauv MHCC97-H hlwb los ntawm Fas- thiab mitochondria-mediated caspase-dependent txoj hauv kev hauv tib neeg HCC hlwb.