Acriflavine, nruab nrab Cas: 8048-52-0 Txiv kab ntxwv rau liab mus rau liab-xim av hmoov
| Catalog Number | xwm 90521 |
| Khoom npe | Acriflavine, nruab nrab |
| CAS | 8048-52-0 |
| Molecular Formula | C14H14ClN3 |
| Molecular Luj | 259.73 ib |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 3824993 ib |
Khoom Specification
| Qhov tshwm sim | Txiv kab ntxwv mus rau liab mus rau liab-xim av hmoov |
| Assay | 99% |
| AS | 10 ppm max |
| Poob rau ziab | 8% max |
| Dej insoluble | 0.5% max |
| Sulfated tshauv | 3.5% max |
| Kev ntsuam xyuas cov ntsiab lus chlorine qhuav @ 105 Deg C rau 2 teev | 13.3 - 15.8% |
Feem ntau cov tshuaj tiv thaiv kab mob tsis tuaj yeem tshem tawm cov qog, ua rau kev txhim kho cov tshuaj tiv thaiv thiab kab mob rov qab.Hedgehog signaling plays lub luag haujlwm tseem ceeb thaum lub sij hawm embryonic txoj kev loj hlob, tab sis kuj koom nrog hauv kev loj hlob qog noj ntshav, kev loj hlob, thiab metastasis.Hedgehog receptor Patched (Ptc) yog Hedgehog signaling hom noob uas yog overexpressed nyob rau hauv ntau lub hlwb.Ntawm no, peb qhia txog kev sib txuas ntawm Ptc thiab tiv thaiv kev kho mob, thiab muab kev pom tshiab rau Ptc muaj nuj nqi.Ptc raug tshem tawm ntawm cov ntshav plasma thaum muaj kev cuam tshuam nrog nws cov ligand Hedgehog, lossis thaum kho cov hlwb nrog Hedgehog signaling antagonist cyclopamine.Nyob rau hauv ob qho tib si, tom qab incubation ntawm cov hlwb nrog doxorubicin, ib tug chemotherapeutic neeg sawv cev uas yog siv rau kev kho mob ntawm cov qog nqaij hlav recurrent, peb pom ib tug inhibition ntawm lub efflux ntawm doxorubicin los ntawm Hedgehog- teb fibroblasts, thiab ib tug nce ntawm doxorubicin tsub zuj zuj nyob rau hauv ob yam mob qog noj ntshav. cov kab xovtooj ntawm tes uas paub tias qhia txog aber rant theem ntawm Hedgehog signaling Cheebtsam.Siv cov txheej txheem heterologous qhia, peb nruj me ntsis qhia tias kev qhia ntawm tib neeg Ptc tau pom zoo rau kev loj hlob inhibition los ntawm ntau cov tshuaj los ntawm cov kws kho mob xws li doxorubicin, methotrexate, temozolomide, thiab 5-fluorouracil.Kev tawm tsam rau doxorubicin cuam tshuam nrog Ptc muaj nuj nqi, raws li qhia siv kev hloov pauv los ntawm Gorlin's syndrome cov neeg mob uas Ptc-mediated nyhuv ntawm Hedgehog signaling ploj lawm.Peb cov txiaj ntsig tau pom tias Ptc koom nrog hauv kev siv tshuaj yeeb tshuaj thiab tshuaj tiv thaiv ntau yam, thiab qhia tias Ptc pab txhawb rau kev kho mob ntawm cov qog nqaij hlav cancer.
