Cov khoom

1. Lub hom phiaj ntawm txoj kev tshawb no yog los tsim ib qho yooj yim pharmacokinetic-pharmacodynamic (PK-PD) qauv uas tuaj yeem ua tus yam ntxwv ntawm lub sijhawm ua tiav ntawm kev hloov pauv hauv platelet suav los kwv yees qhov pib thiab qib ntawm thrombocytopenia, uas txwv tsis pub siv cov tshuaj hnyav. Anticancer agent 5-fluorouracil (5-FU), nyob rau hauv nas.2. Platelet suav tau raug ntsuas hauv cov nas tom qab txhaj tshuaj ntawm ntau hom 5-FU rau 4 hnub kom tau txais cov ntaub ntawv rau kev tshuaj xyuas ntawm tus qauv PK-PD.Peb cov qauv PK-PD muaj ob chav PK qauv, nrog rau peb qhov chaw rau PD qauv thiab 10 tus qauv PK-PD qauv tsis.3. Tom qab 5-FU kev kho mob, platelet suav tsis tu ncua mus rau qib nadir, pom qhov rov qab mus rau saum theem pib ua ntej rov qab mus rau theem pib.Nadir platelet suav thiab rebounds txawv nrog rau qib AUC0-∞.Qhov kawg PK-PD qauv ua tau zoo qhia cov ntaub ntawv platelet suav thiab qhov kawg PD tsis tau kwv yees nrog qhov tseeb.4. PK-PD qauv thiab simulation no tuaj yeem sawv cev rau cov cuab yeej tseem ceeb rau kev ntsuas thiab kwv yees lub sijhawm ua tiav ntawm kev hloov pauv hauv cov ntshav suav, thiab tuaj yeem pab txhawb kev txhim kho cov tswv yim kho mob nrog 5-FU thiab kev ntsuas ntawm ntau yam tshuaj tiv thaiv kab mob tshiab. uas nyuaj rau kev soj ntsuam hauv tib neeg.