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PMSF Cas: 329-98-6 98.0% Dawb crystalline hmoov Phenylmethanesulfonyl fluoride (PMSF)

Lus piav qhia luv luv:

Catalog Number: xwm 90250
Cas: 329-98-6 : kuv
Molecular Formula: C7H7FO2S
Molecular Luj: 174.1927 ib
Muaj: Hauv Tshuag
Nqe:  
Prepack: 5g ua 20
Ntim Pob: Thov Quote

 

 

 

 

 

 


Product Detail

Khoom cim npe

Catalog Number xwm 90250

Khoom npe

Tom ntej: Phenylmethanesulfonyl Fluoride (PMSF)

CAS

329-98-6 : kuv

Molecular Formula

C7H7FO2S

Molecular Luj

174.1927 ib
Cov ntaub ntawv khaws cia Ambient

Harmonized tariff Code

29049900 ib

 

Khoom Specification

Assay ≥98.0% HPLC
Qhov tshwm sim dawb crystalline hmoov

 

PMSF yog ib qho irreversible serine / cysteine ​​​​protease inhibitor feem ntau siv rau hauv kev npaj ntawm cell lysates.

 

Kev tshawb fawb hauv vitro: PMSF (2 mM) inhibited carbachol-stimulated inositol phosphate tsub zuj zuj los ntawm tsuas yog 15% -19% nyob rau hauv lub xub ntiag ntawm Li +.Qhov inhibition ntawm phosphoinositide turnover los ntawm PMSF yog vim ib lossis ntau cov kauj ruam tom qab kev tawg ntawm phosphoinositide [1].PMSF inhibits acylation ntawm inositol residues ntawm GPI intermediates hauv cov hlab ntsha ntawm T. brucei.PMSF inhibits glycolipid C tsim tab sis tsis fatty acid hloov kho hauv vitro.PMSF inhibits ntxiv ntawm GPI acylation thiab ethanolamine phosphatase hauv procyclic trypanosomes, tab sis tsis nyob hauv Hela hlwb [2].

Hauv vivo cov kev tshawb fawb: PMSF (0.1 mL / 10 g b.wt, ip) tsim cov tshuaj tiv thaiv kab mob, raws li qhia los ntawm kev siv tshuaj ntau ntxiv hauv % MPE hauv kev ntsuas tus tw-flick latency, tab sis ua tsis tiav los ua kom pom tseeb koob tshuaj tiv thaiv lub cev muaj zog.Cov nas uas tau txais kev txhaj tshuaj intraperitoneal ntawm PMSF tau nthuav tawm cov teebmeem cannabinoid nrog rau kev tiv thaiv kev tiv thaiv, hypothermia thiab immobility nrog ED50 qhov tseem ceeb ntawm 86, 224 thiab 206 mg / kg, feem.PMSF (30 mg / kg) pretreatment txhim kho cov teebmeem ntawm anandamide ntawm tail-flick cov lus teb (antinociception), locomotor kev ua ub no thiab kev txav mus los ntawm 5-fold, 10-fold thiab 8-fold, feem [3].

Kev sim tsiaj: Txiv neej ICR nas uas hnyav 18 txog 25 g tau siv rau hauv qhov kev xeem.PMSF tau yaj nyob rau hauv cov noob hnav roj thiab muab tshuaj intraperitoneally hauv ib ntim ntawm 0.1 mL / 10 g b.wt.Ib txwm tswj hwm PMSF 10 feeb ua ntej txhaj tshuaj anandamide lossis txhaj tshuaj tsheb.Cov nas tau nkag mus rau hauv chav ntsuas ntsuas ib hmos yam tsis muaj kev cuam tshuam ntawm zaub mov lossis dej.Tom qab txhaj tshuaj anandamide lossis kev tswj xyuas lub tsheb, txhua tus tsiaj tau raug soj ntsuam raws li hauv qab no: 5 feeb rau cov lus teb tail-flick latency (antinociceptive) thiab 5 mus rau 15 feeb rau kev ua haujlwm (lub cev muaj zog);los yog 5 feeb rau qhov kub thiab txias (qhov quav) thiab lub nplhaib Immobilization (catalepsy) rau 5 mus rau 10 feeb.


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    PMSF Cas: 329-98-6 98.0% Dawb crystalline hmoov Phenylmethanesulfonyl fluoride (PMSF)