![3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas:54827-17-7 99% Featured duab](http://cdn.globalso.com/xdbiochems/54827-17-71.jpg)
3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine CAS: 54827-17-7 99%
| Catalog Number | xwm 90518 |
| Khoom npe | 3,3',5,5'-Tetramethyl-[1,1'-biphenyl]-4,4'-diamine |
| CAS | 54827-17-7 ib |
| Molecular Formula | C16H20N2 |
| Molecular Luj | 240.34 Nws |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 292159 0 |
Khoom Specification
| Qhov tshwm sim | Dawb, tawm dawb mus rau grey los yog daj hmoov |
| Assay | > 99% |
| Poob rau ziab | <2.0% |
| Kev tshawb fawb siv nkaus xwb, tsis yog siv rau tib neeg | kev tshawb fawb siv xwb, tsis yog rau tib neeg siv |
Ricin toxin (RT) yog qhov thib ob feem ntau cov tshuaj lom neeg tuag paub;nws tau raug xaiv los ntawm CDC ua tus neeg sawv cev xaiv.RT yog tsim los ntawm cov noob taum castor;kwv yees li 50,000 tons ntawm RT tau tsim txhua xyoo raws li cov khoom lag luam ntawm cov roj castor.RT muaj ob lub subunits, ribotoxic A saw (RTA) thiab galactose-binding B chain (RTB).RT khi rau tag nrho cov kab mob mammalian thiab ib zaug nyob rau hauv, ib qho RTA catalytically inactivates tag nrho cov ribosomes nyob rau hauv ib lub cell.Kev tswj hwm raws li aerosol, RT ua rau lub ntsws puas sai thiab fibrosis tom qab tuag.Tsis muaj Food and Drug Administration-pom zoo cov tshuaj tiv thaiv thiab kev kho mob tsuas yog siv tau hauv thawj ob peb teev tom qab kis tau.Peb tau tsim cov tshuaj tiv thaiv RTA recombinant uas muaj ob qhov kev hloov pauv V76M/Y80A (RiVax).Cov protein yog qhia nyob rau hauv Escherichia coli thiab yog nontoxic thiab immunogenic nyob rau hauv nas, luav, thiab tib neeg.Thaum txhaj tshuaj tiv thaiv nas raug sib tw nrog kev txhaj tshuaj, aerosolized, lossis kev tswj hwm qhov ncauj (gavaged) RT, lawv raug tiv thaiv tag nrho.Peb tau tam sim no de veloped lub thermostable, txhuas-adjuvant-muaj formulation ntawm RiVax thiab sim nws nyob rau hauv rhesus macaques.Tom qab peb txhaj tshuaj, cov tsiaj tau tsim cov tshuaj tiv thaiv uas tiv thaiv lawv tag nrho los ntawm kev siv tshuaj tua kab mob aerosolized RT.Cov tshuaj tiv thaiv no neutralized RT thiab sib tw rau qib sib txawv nrog lub vaj huam sib luag ntawm neutralizing thiab nonneutralizing nas monoclonal antibodies paub kom paub txog cov epitopes ntawm haiv neeg RTA.Qhov txiaj ntsig ntawm kev sib tw antibody profile tuaj yeem sawv cev rau kev kos npe ntawm kev tiv thaiv kab mob.Qhov tseem ceeb, tib qhov kos npe tau pom siv sera los ntawm RiVax-tiv thaiv tib neeg.
