Cov khoom

Kev mob ntsws ntev ntev thiab kho kho, suav nrog fibrosis, tau raug npaj los ua cov tseem ceeb rau kev mob ntsws asthma pathophysiology.Cov kev tshawb fawb yav dhau los ntawm cov hlab ntsws fibrosis tau ua feem ntau hauv cov mob ntsws asthmatic me me thiab nruab nrab ntawm subepithelial "hauv qab daus daim nyias nyias" (SBM).Txoj kev tshawb fawb tam sim no tau tsim los ntsuas cov pa loj SBM tuab thiab submucosal collagen deposition, raws li ntsuas los ntawm peb txoj kev sib txawv collagen staining, hauv endobronchial biopsies los ntawm 17 mob hnyav, cuaj nruab nrab, thiab xya mob hawb pob, nrog rau yim yam kev tswj hwm ib txwm muaj.Cov ntaub so ntswg eosinophils thiab transforming growth factor-beta (TGF-beta) immunoreactivity kuj tau kuaj.Tsis muaj qhov sib txawv tseem ceeb hauv SBM thickness, submucosal collagen deposition, eosinophil tooj, los yog TGF-beta zoo hlwb ntawm peb pawg neeg mob hawb pob thiab cov kev tswj ib txwm muaj.Nws tsuas yog thaum soj ntsuam tag nrho cov mob hawb pob (n = 33) ua ke, uas ib txwm ua tuab tuab SBM (p = 0.04), raws li kev ntsuas los ntawm collagen hom III immunostaining, tau pom zoo li piv nrog cov kev tswj ib txwm muaj.Txawm hais tias qhov sib txawv no, tsis muaj qhov sib txawv tseem ceeb hauv qhov nyiaj ntawm submucosal collagen deposition thiab tus naj npawb ntawm eosinophils lossis TGF-beta qhia cov hlwb thaum muab piv rau tag nrho cov mob hawb pob thiab cov kev tswj ib txwm muaj.Tsis tas li ntawd, tsis muaj kev sib raug zoo tseem ceeb ntawm collagen deposition thiab eosinophil suav, TGF-beta qhia theem, FEV1, lossis lub sijhawm mob hawb pob.Cov txiaj ntsig no qhia tau hais tias txawm hais tias muaj zog collagen deposition hauv SBM ntawm cov hlab cua loj yog ib yam ntawm cov mob hawb pob, nws yuav tsis piav txog qhov sib txawv ntawm qhov mob hawb pob.