Cov khoom

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) yog cov zinc-muaj carboxypeptidase thiab cuam tshuam rau fibrinolysis.TAFIa inhibitors yog li xav kom ua raws li cov neeg ua haujlwm profibrinolytic.Peb nyuam qhuav tshaj tawm cov qauv tsim thiab kev sib txuas ntawm selenium-muaj inhibitors ntawm TAFIa thiab lawv cov haujlwm inhibitory.Ntawm no peb tshaj tawm cov qauv siv lead ua ntawm muaj zog selenium-, sulfur-, thiab phosphinic acid-muaj inhibitors khi rau porcine pancreatic carboxypeptidase B (ppCPB).ppCPB yog TAFIa homologue thiab yog surrogate TAFIa rau crystallographic tsom xam.Cov qauv siv lead ua ntawm ppCPB complexed nrog selenium compound 1a, nws cov sulfur analogue 2, thiab phosphinic acid derivative EF6265 tau txiav txim siab ntawm 1.70, 2.15, thiab 1.90 Å daws teeb meem, feem.Txhua tus inhibitor khi rau qhov chaw nquag ntawm ppCPB zoo ib yam li cov uas tau pom rau yav dhau los qhia inhibitors.Yog li, hauv cov complexes, selenium, sulfur, thiab phosphinic acid oxygen ua haujlwm rau zinc hauv ppCPB.Qhov no yog thawj zaug kev soj ntsuam thiab tshaj tawm ntawm selenium koom tes rau zinc hauv CPB.