Cov khoom

Neuroblastoma, mob qog noj ntshav ntawm lub paj hlwb, yog cov qog nqaij hlav ntau tshaj plaws hauv cov menyuam yaus.MYCN amplification thiab nce BDNF / TrkB signaling yog cov yam ntxwv ntawm cov qog nqaij hlav;tseem, tsuas yog ˜25% ntawm cov qog malignant pom cov yam ntxwv no.Yog li, kev txheeb xyuas cov biomarkers ntxiv thiab cov hom phiaj kho mob yog qhov tseem ceeb.Raws li aminoacylase 1 (ACY1), ib qho amino acid deacetylase, yog cov qog nqaij hlav hauv lub ntsws thiab lub raum cell carcinomas, peb tau tshawb xyuas seb nws los yog lwm tus neeg hauv tsev neeg aspartoacylase (ASPA, aminoacylase 2) lossis aminoacylase 3 (ACY3) tuaj yeem pab. kev ua haujlwm zoo sib xws hauv neuroblastoma.Aminoacylase qhia tau tshuaj xyuas hauv TrkB-positive, MYCN-amplified (SMS-KCNR thiab SK-N-BE) thiab TrkB-negative, non-MYCN-amplified (SK-N-AS, SK-N-SH, SH-SY5Y thiab SH-EP) neuroblastoma cell kab.Txhua aminoacylase tau nthuav tawm qhov txawv ntawm qhov chaw hauv cheeb tsam (piv txwv li, cytosolic ACY1, membrane-associated ASPA thiab nuclear ACY3).Thaum SK-N-SH hlwb raug kho nrog cov tshuaj neural sib txawv (xws li, retinoic acid thiab cAMP) hauv xov xwm uas muaj 10% cov ntshav, ACY1 tsuas yog cov aminoacylase uas nws cov lus qhia tau raug kho.ASPA tau qhia feem ntau hauv SH-EP hlwb ntawm glial sublineage.ACY3 tau nthuav tawm ntau dua hauv TrkB-zoo, MYCN-amplified kab.Tag nrho peb cov aminoacylases tau qhia nyob rau hauv ib txwm tib neeg lub qog adrenal, ib qho chaw ntawm neuroblastoma keeb kwm, tab sis tsuas yog ACY1 thiab ACY3 pom pom pom pom hauv thawj cov qog nqaij hlav neuroblastoma.Bioinformatics cov ntaub ntawv mining ntawm Kaplan-Meier ciaj sia taus qhia tau hais tias siab ACY3 kev qhia muaj feem cuam tshuam nrog kev ua haujlwm tsis zoo, qhov kev qhia qis ntawm ACY1 lossis ASPA yog cuam tshuam nrog kev pom tsis zoo.Cov ntaub ntawv no qhia tias aminoacylase kev qhia yog dysregulated hauv neuroblastoma