5-Methylphenaziniummethosulfate Cas: 299-11-6 99% Tsaus ntsuab rau xim av hmoov
| Catalog Number | xwm 90224 |
| Khoom npe | 5-Methylphenazinium Methosulfate |
| CAS | 299-11-6 : kuv |
| Molecular Formula | C14H14N2O4S |
| Molecular Luj | 306.337 ib |
| Cov ntaub ntawv khaws cia | -15 rau -20 ° C |
| Harmonized tariff Code | 2933980 :ib |
Khoom Specification
| Melting Point | 158-160 ° C (txog) (lit.) |
| Assay | 99% |
| Daim ntawv | Khoom |
| Qhov tshwm sim | Tsaus ntsuab rau xim av hmoov |
Cov n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) thiab docosahexaenoic acid (DHA) tau pom tias yuav txhim khu cov nyhuv ntawm chemotherapeutic tshuaj nyob rau hauv kev tshawb fawb soj ntsuam nyob rau hauv cov neeg mob qog noj ntshav thiab induce apoptotic qog cell tuag nyob rau hauv vitro.Txog tam sim no, EPA thiab DHA yeej tsis tau tshawb xyuas ntau yam myeloma (MM).Tib neeg myeloma hlwb (L363, OPM-1, OPM-2 thiab U266) thiab ib txwm peripheral ntshav mononuclear hlwb raug rau EPA thiab DHA, thiab cov teebmeem ntawm mitochondrial muaj nuj nqi thiab apoptosis, caspase-3 activation, noob qhia thiab tshuaj toxicity raug ntsuas.Kev raug rau EPA thiab DHA induced apoptosis thiab nce rhiab heev rau bortezomib hauv MM hlwb.Qhov tseem ceeb, lawv tsis cuam tshuam txog kev muaj peev xwm ntawm tib neeg peripheral mononuclear hlwb.Cov neeg xa xov liaison RNA qhia arrays tau pom tias EPA thiab DHA modulated genes koom nrog ntau txoj hauv kev qhia suav nrog nuclear factor (NF) κB, Notch, Hedgehog, oxidative stress thiab Wnt.EPA thiab DHA inhibited NFκB kev ua si thiab induced apo ptosis los ntawm mitochondrial perturbation thiab caspase-3 activation.Peb txoj kev tshawb fawb qhia tias EPA thiab DHA ua rau muaj kev xaiv cytotoxic hauv MM thiab nce rhiab heev rau bortezomib thiab hu rau kev tshawb nrhiav ntxiv rau hauv daim ntawv thov ntawm cov n-3 polyunsaturated fatty acids hauv kev kho ntawm MM.
