Cov khoom

Txhawm rau tshawb xyuas cov txiaj ntsig ntawm cov roj spearmint ntawm emphysema-zoo li kev hloov pauv thiab kev qhia ntawm qog necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) thiab cov ntaub so ntswg inhibitor ntawm metalloproteinase -1 (TIMP-9) nyob rau hauv lipopolysaccharide (LPS) kho nas.Cov nas tau muab faib ua kev tswj hwm, dexamethasone (0.3 mg x kg(-1)), thiab spearmint roj (10, 30,100 mg x kg(-1)) pawg.Txhua pawg tau kho nrog saline, dexamethasone, thiab spearmint roj raws li 4 lub lis piam.Tom qab ntawd tag nrho thiab sib txawv ntawm cov qe ntshav dawb suav hauv bronchoalveolar lavage kua (BALF) tau ua tiav.Cov kev hloov pauv pathologic ntawm lub ntsws xws li cov qauv alveolar, cov hlab ntsws o, thiab goblet cell metaplasia tau pom los ntawm HE thiab AB-PAS staining.Kev nthuav qhia ntawm TNF-alpha, IL-1beta, TIMP-1 thiab MMP-9 tau ntsuas. Ob leeg spearmint thiab dexamethasone txo qis kev puas tsuaj ntawm pulmonary alveolus.Tag nrho thiab txawv cov qe ntshav dawb suav hauv BALF suav nrog neutrophile thiab lymphocyte ntawm spearmint roj 100 mg x kg (-1) thiab dexamethasone pawg tau txo qis, thiab goblet cell metaplasia kuj inhibited.Dexamethasone muaj cov nyhuv inhibitory ntawm kev qhia ntawm TNF-alpha, IL-1beta, TIMP-1 thiab MMP-9.Spearmint roj 30, 100 mg x kg (-1) txo qis TNF-alpha thiab IL-1beta feem.Spearmint roj 10, 30 thiab 100 mg x kg (-1) tsis muaj kev cuam tshuam rau kev qhia ntawm TIMP-1, tab sis tuaj yeem txo qhov kev qhia ntawm MMP-9 hauv cov ntaub so ntswg.Spearmint roj muaj kev tiv thaiv rau cov nas uas muaj kev hloov pauv, vim nws txhim kho kev puas tsuaj alveolar, pulmonary o, thiab goblet cell metaplasia.Cov txheej txheem yuav suav nrog txo TNF-alpha, IL-1beta cov ntsiab lus thiab inhibiting overexpression ntawm matrix metalloproteinase-9 nyob rau hauv cov ntaub so ntswg ntsws.