Rapamycin los ntawm Streptomyces hygroscopicus CAS: 53123-88-9 Dawb mus rau dawb los yog daj crystalline hmoov
| Catalog Number | xwm 90356 |
| Khoom npe | Rapamycin los ntawm Streptomyces hygroscopicus |
| CAS | 53123-88-9 |
| Molecular Formula | C51H79NO13 |
| Molecular Luj | 914.17 ib |
| Cov ntaub ntawv khaws cia | -20 ° C |
| Harmonized tariff Code | 2942000000000000 |
Khoom Specification
| Assay | 99% |
| Qhov tshwm sim | Dawb mus rau dawb los yog daj crystalline hmoov |
Rapamycin, ib qho tshuaj uas tau pom tias yuav ua rau kom muaj sia nyob hauv cov nas, inhibits lub hom phiaj ntawm rapamycin (TOR) txoj hauv kev, txoj hauv kev tseem ceeb uas tswj kev loj hlob ntawm tes thiab lub zog.Nws tau raug xav tias rapamycin thiab kev txwv tsis pub noj zaub mov (DR) txuas ntxiv lub neej los ntawm cov txheej txheem / txoj hauv kev zoo sib xws.Siv microarray tsom xam, peb piv cov ntaub ntawv ntawm cov ntaub so ntswg adipose dawb los ntawm cov nas noj rapamycin lossis DR-kev noj haus rau 6 lub hlis.Multidimensional scaling thiab heatmap analyses pom tau hais tias rapamycin yeej tseem ceeb tsis muaj kev cuam tshuam rau cov ntaub ntawv transcriptome piv rau DR.Piv txwv li, tsuas yog rau transcripts tau hloov pauv loj heev los ntawm rapamycin thaum nas noj DR pom qhov hloov pauv tseem ceeb hauv ntau dua 1000 cov ntawv sau tseg.Siv txoj kev tshawb nrhiav kev txawj ntse, peb pom tias stearate biosynthesis thiab circadian atherosclerosis signaling tau hloov pauv los ntawm DR.Peb qhov kev tshawb pom uas qhia tias DR, tab sis tsis yog rapamycin, muaj kev cuam tshuam rau cov ntaub ntawv ntawm cov ntaub so ntswg adipose, qhia tias ob qho kev ua haujlwm no ua rau kom muaj sia nyob los ntawm kev sib txawv / txoj hauv kev.
