Protein Kinase Supplement KT5823 CAS: 126643-37-6
| Catalog Number | xwm 90398 |
| Khoom npe | Protein Kinase Ntxiv KT5823 |
| CAS | 126643-37-6 |
| Molecular Formula | C29H25N3O5 |
| Molecular Luj | 495.53 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 293499 0 |
Khoom Specification
| Qhov tshwm sim | Dawb hmoov |
ATP-gated P2X3 receptors yog cov hloov pauv tseem ceeb ntawm nociceptive stimuli thiab yuav luag tshwj xeeb tshaj tawm los ntawm kev hnov lus ganglion neurons.Hauv nas trigeminal ganglion (TG), P2X3 receptor muaj nuj nqi yog npaj txhij txog txhim kho los ntawm pharmacological block ntawm natriuretic peptide receptor-A (NPR-A), qhia txog lub peev xwm inhibitory luag hauj lwm ntawm endogenous natriuretic peptides nyob rau hauv nociception kho los ntawm P2X3 receptors.Tsis muaj kev hloov pauv hauv P2X3 cov protein qhia qhia tau hais tias muaj kev hloov pauv nyuaj uas nws cov txheej txheem rau kev txo qis P2X3 receptor muaj nuj nqi tseem tsis tau meej. Kom qhia meej txog cov txheej txheem no hauv nas TG kab lis kev cai, peb txwv NPR-A kev taw qhia nrog siRNA ntawm endogenous agonist BNP, lossis NPR-A. blocker tshuaj.Yog li, peb tau tshawb xyuas cov kev hloov pauv hauv P2X3 receptor tis nyob rau hauv lipid raft membrane compartment, lawv lub xeev phosphorylation, nrog rau lawv txoj haujlwm nrog patch clamping.Kev ncua sij hawm ntawm P2X3 desensitization yog ib lub tswv yim rau kev txhim kho anantin-induced ntawm P2X3 kev ua.Anant hauv daim ntawv thov ua rau muaj qhov tshwj xeeb P2X3 receptor redistribution rau lipid raft compartment thiab txo P2X3 serine phosphorylation, ob qhov tshwm sim uas tsis muaj kev cuam tshuam.Ib qho inhibitor ntawm cGMP-dependent protein kinase thiab siRNA-mediated knockdown ntawm BNP ua raws li cov nyhuv ntawm anantin.Peb pom tau hais tias nyob rau hauv nas trigeminal neurons endogenous BNP ua rau NPR-A receptors los txiav txim siab constitutive kev nyuaj siab ntawm P2X3 receptor muaj nuj nqi.Tonic inhibition ntawm P2X3 receptor kev ua haujlwm los ntawm BNP / NPR-A / PKG txoj hauv kev tshwm sim los ntawm ob lub tswv yim sib txawv: P2X3 serine phosphorylation thiab receptor redistribution rau cov tsis-raft daim nyias nyias.Cov txheej txheem tshiab ntawm kev tswj hwm receptor no yuav yog lub hom phiaj rau kev tshawb fawb yav tom ntej txhawm rau txo qis dysregulated P2X3 receptor kev ua haujlwm hauv qhov mob ntev.
