Cov khoom

Europium(III) thiab terbium(III) complexes, namely [Eu(dpq)(DMF)2(NO3)3] (1), [Eu(dppz)2(NO3)3] (2), [Tb(dpq) ) (DMF)2Cl3] (3), thiab [Tb(dppz)(DMF)2Cl3] (4), qhov twg dipyrido[3,2-d:2',3'-f]quinoxaline (dpq hauv 1 thiab 3) , dipyrido [3,2-a: 2',3'-c] phenazine (dppz hauv 2 thiab 4) thiab N, N'-dimethylformamide (DMF) tau raug cais tawm, tshwj xeeb ntawm lawv cov ntaub ntawv physicochemical, kev tshawb fawb luminescence thiab lawv cov kev cuam tshuam. Nrog DNA, serum albumin protein thiab yees duab-induced DNA cleavage kev ua tau kawm.X-ray siv lead ua qauv ntawm complexes 1-4 qhia discrete mononuclear Ln(3+)-raws li qauv.The Eu(3+) in [Eu(dpq)(DMF)2(NO3)3] (1) and [Eu(dppz)2(NO3)3] (2) as [Eu(dppz)2(NO3)3 ]·dppz (2a) txais yuav kaum-coordinated bicapped dodecahedron qauv nrog ib tug bidentate N, N-donor dpq ligand, ob DMF thiab peb NO3(-) anions nyob rau hauv 1 thiab ob bidentate N, N-tus pub dppz ligands thiab peb NO3 ( -) anions nyob rau hauv 2. Complexes 3 thiab 4 qhia ib tug xya-coordinated mono-capped octahedron qauv uas Tb(3+) muaj bidentate dpq/dppz ligands, ob DMF thiab peb Cl(-) anions.Cov complexes yog cov luminescent heev nyob rau hauv qhov qhia tau hais tias muaj txiaj ntsig yees duab-zoo siab lub zog hloov los ntawm dpq / dppz kav hlau txais xov rau Ln (3+) los tsim kom muaj lub neej ntev emissive zoo siab rau cov yam ntxwv f → f hloov.Lub sij hawm daws teeb meem luminescence spectra ntawm complexes 1-4 qhia ib tug nqaim emission bands ntaus nqi rau lub (5) D0 → (7) F (J) thiab (5) D4 → (7) F (J) ff zaus ntawm Eu(3 +) thiab Tb(3+) ions feem.Tus naj npawb ntawm sab hauv-sphere dej molecules (q) tau txiav txim siab los ntawm luminescence lifetime ntsuas hauv H2O thiab D2O lees paub ligand-piv cov tshuaj tiv thaiv nrog dej hauv kev daws.Cov complexes qhia qhov tseem ceeb binding propensity rau CT-DNA muab binding qhov tseem ceeb nyob rau hauv thaj tsam ntawm 1.0 × 10 (4) - 6.1 × 10 (4) M (-1) nyob rau hauv qhov kev txiav txim 2, 4 (dppz) > 1, 3 (dpq).DNA khi cov ntaub ntawv qhia DNA groove khi nrog ib nrab intercalation xwm ntawm cov complexes.Tag nrho cov complexes tseem qhia txog kev sib txuas (K(BSA) ∼ 10(5) M(-1)) rau cov protein ntau hauv bovine serum albumin (BSA).Qhov kev siv ntawm lub sij hawm-gated luminescence spectral bands txhim khu kev qha nrog qhov nce DNA concentration nyob rau hauv aqueous buffer nruab nrab vim los ntawm kev hloov pauv ntawm cov dej khi thaum muaj kev cuam tshuam nrog DNA, yog li txo qis tsis-radiative quenching los ntawm OH oscillator.Complexes 1-4 zoo cleave supercoiled (SC) ds-DNA rau nws cov nicked ncig (NC) daim ntawv ntawm raug UV-A lub teeb ntawm 365 nm los ntawm kev tsim ntawm singlet oxygen ((1) O2) thiab hydroxyl radicals (HO˙) raws li cov reactive oxygen hom ntawm micromolar concentrations nyob rau hauv physiological tej yam kev mob.