Cov khoom

Qhov hnyav ntawm microbial tsis kam ua ke nrog qhov tsis muaj cov tshuaj tua kab mob tshiab tau ua rau muaj kev txaus siab rau kev tsim cov tshuaj tiv thaiv kab mob peptides (AMPs) raws li kev kho tshiab.Hauv txoj kev tshawb no, peb tau soj ntsuam cov kev ua haujlwm ntawm cov tshuaj tua kab mob ntawm ob lub peptides luv luv, uas yog, RRIKA thiab RR.Cov peptides tau nthuav tawm cov tshuaj tiv thaiv kab mob muaj zog tiv thaiv Staphylococcus aureus, thiab lawv cov tshuaj tiv thaiv kab mob tau txhim kho tau zoo los ntawm kev ntxiv peb cov amino acids hauv C terminus, uas ua rau nce amphipathicity, hydrophobicity, thiab net nqi.Tsis tas li ntawd, RRIKA thiab RR tau pom tias muaj cov kab mob tseem ceeb thiab ceev ceev tiv thaiv kev soj ntsuam thiab tshuaj tiv thaiv Staphylococcus cais, suav nrog methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA) , linezolid-resistant S. aureus, thiab methicillin-resistant Staphylococcus epidermidis.Nyob rau hauv sib piv rau ntau yam ntuj tsim AMPs, RRIKA thiab RR khaws cov kev ua ub no nyob rau hauv lub xub ntiag ntawm physiological concentrations ntawm NaCl thiab MgCl2.Ob leeg RRIKA thiab RR txhim kho kev tua ntawm lysotaphin ntau dua 1,000-fold thiab tshem tawm MRSA thiab VRSA cais nyob rau hauv 20 min.Tsis tas li ntawd, cov peptides tau nthuav tawm tau zoo tshaj hauv kev txo qis cov biofilms ntawm S. aureus thiab S. epidermidis piv rau cov txiaj ntsig nrog cov tshuaj tua kab mob.Peb qhov kev tshawb pom qhia tias cov teebmeem staphylocidal ntawm peb cov peptides yog los ntawm permeabilization ntawm cov kab mob hauv daim nyias nyias, ua rau kom cov cytoplasmic cov ntsiab lus thiab cell tuag.Tsis tas li ntawd, peptides tsis muaj tshuaj lom rau HeLa hlwb ntawm 4- txog 8-fold lawv cov tshuaj tiv thaiv kab mob.Lub zog thiab ntsev-insensitive antimicrobial kev ua ub no ntawm cov peptides tam sim no ib tug txaus nyiam kev kho mob neeg sib tw rau kev kho mob ntawm multidrug-resistant S. aureus kab mob.