Cov khoom

Kaum tsib platinum (II)-raws li metallointercalators tau raug tsim los siv hloov pauv 1,10-phenanthroline (phen) ligands, suav nrog 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- Phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) thiab dipyrido[3,2-d : 2',3'-f]quinoxaline (dpq), thiab achiral ethylenediamine (en) thiab chiral ancillary ligands 1S, 2S-diaminocyclohexane (S, S-dach) thiab 1R,2R-diaminocyclohexane (R, R-dach) .Lawv cytotoxicity nyob rau hauv L1210 murine leukemia cell kab tau txiav txim siab siv kev loj hlob inhibition kev soj ntsuam.Cov hlau cytotoxic feem ntau yog cov uas muaj S, S-dach ancillary ligands thiab 5-CH3-phen intercalating ligands.Ib qho metallointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), qhia txog 5-10-fold nce hauv cytotoxicity piv rau cov neeg ua haujlwm kho mob cisplatin.Los ntawm DNA binding thwmsim pom tau tias tsis muaj qhov sib txawv tseem ceeb ntawm ib qho ntawm cov hlau complexes, qhia tias tsis yog DNA binding affinity los yog hom kev khi / DNA adduct tsim yog tus txiav txim ib leeg ntawm cytotoxicity ntawm tsev neeg ntawm platinum (II)-raws li. metallointercalators.