Cov khoom

Idiopathic pulmonary fibrosis yog xav tias muaj kev raug mob ntsws los ntawm cov pa oxygen reactive (ROS), uas nyob rau hauv lem yog ua raws li qhov txawv txav fibrosis.Ib qho kev hloov pauv kev loj hlob (TGF)-β1-induced nce hauv myofibroblast tus naj npawb plays lub luag haujlwm tseem ceeb hauv qhov txawv txav no.Peb nyuam qhuav pom tias mepenzolate bromide (mepenzolate), uas tau siv los kho cov kab mob plab, muaj ROS-txo cov khoom.Hauv kev tshawb fawb tam sim no, peb tau tshuaj xyuas cov txiaj ntsig ntawm mepenzolate ntawm bleomycin-induced pulmonary fibrosis thiab lub ntsws tsis ua haujlwm hauv cov nas.Qhov hnyav ntawm pulmonary fibrosis tau soj ntsuam los ntawm kev soj ntsuam histopathologic thiab kev txiav txim siab ntawm qib hydroxyproline.Lub ntsws mechanics (elastance) thiab kev ua pa ua pa [forced vital capacity (FVC)] raug soj ntsuam siv lub tshuab ua pa uas tswj tau lub computer.Kev ua pa ua pa kuj raug soj ntsuam los ntawm kev saib xyuas percutaneous arterial oxygen saturation (SpO2).Intratracheal kev tswj hwm ntawm mepenzolate ua ntej kev kho mob bleomycin txo qis ntawm pulmonary fibrosis thiab kev hloov hauv lub ntsws mechanics thiab ua rau muaj kev rov qab zoo ntawm FVC thiab SpO2 piv nrog kev tswj hwm.Tsis tas li ntawd, mepenzolate ua rau muaj kev kho mob txawm tias thaum nws tau noj tom qab kev loj hlob ntawm fibrosis.Kev tswj hwm ntawm mepenzolate kuj tiv thaiv bleomycin-induced pulmonary cell tuag thiab inflammatory teb thiab nce myofibroblast tooj.Mepenzolate kuj txo qis NADPH oxidase kev ua haujlwm thiab nquag TGF-β1 qib lossis nce glutathione S-transferase (GST) kev ua haujlwm thaum muaj kev kho mob bleomycin.Cov txiaj ntsig no qhia tau tias kev tswj hwm intratracheal ntawm mepenzolate txo bleomycin-induced pulmonary fibrosis thiab lub ntsws tsis ua haujlwm hauv cov nas.Cov teebmeem no tuaj yeem yog vim cov tshuaj no inhibitory nyhuv ntawm NADPH oxidase thiab TGF-β1 cov dej num thiab nws cov nyhuv stimulatory ntawm GST.