D-Valine Cas: 640-68-6 C5H11NO2
| Catalog Number | xwm 90291 |
| Khoom npe | D-Valine |
| CAS | 640-68-6 |
| Molecular Formula | C5H11NO2 |
| Molecular Luj | 117.14634 ib |
| Cov ntaub ntawv khaws cia | Chav Temp |
| Harmonized tariff Code | 29224995 ib |
Khoom Specification
| Assay | 99% |
| Qhov tshwm sim | Dawb hmoov |
| Qhov ntom | 1.2000 (kwv yees) |
| Melting point | > 295 ° C (sub.) (lit.) |
| Boiling point | 213.6 ° C ntawm 760 mmHg |
| Flash point | 83 ℃ |
| Refractive Index | -27 ° C = 8, 6 mol / L HCl |
| Solubility | 56 g / L (20 ° C) |
| Dej solubility | 56 g / L (20 ºC) |
| PSA | 63.32.000 Nws |
| LogP | 0.75460 ib |
| Kev sib hloov tshwj xeeb | -27.5 º (c = 5, 5N HCl) |
| Kev ua haujlwm kho qhov muag | [α]23/D −32.0 to −24.0°, c = 8 in 6 M HCl |
Cov poj niam uas muaj cov kab mob antiphospholipid (APS) muaj kev pheej hmoo ntawm kev xeeb tub rov qab (RPL) thiab preeclampsia.Antiphospholipid antibodies (aPL) ncaj qha hloov trophoblast muaj nuj nqi.Kev kho mob nrog qis molecular hnyav heparin (LMWH) txo qhov kev pheej hmoo ntawm RPL tab sis tsis yog preeclampsia.Ntxiv mus, LMWH txhawb nqa trophoblast sFlt-1 tso tawm, ib qho kev tiv thaiv angiogenic cuam tshuam nrog preeclampsia.Txij li thaum vitamin D tsis muaj peev xwm cuam tshuam nrog APS thiab preeclampsia, txoj kev tshawb no nrhiav kev txiav txim siab cov txiaj ntsig ntawm vitamin D ntawm trophoblast muaj nuj nqi hauv kev teeb tsa ntawm aPL thiab LMWH.A tib neeg thawj peb lub hlis twg trophoblast cell kab (HTR8) thiab thawj trophoblast kab lis kev cai tau kho nrog lossis tsis muaj aPL nyob rau hauv lub xub ntiag thiab tsis muaj vitamin D, LMWH los yog ob qho tib si.Trophoblast secretion ntawm inflammatory cytokines thiab angiogenic yam raug ntsuas los ntawm ELISA.Vitamin D ib leeg los yog ua ke nrog LMWH attenuated aPL-induced trophoblast inflammatory teb nyob rau hauv HTR8 hlwb thiab thawj kab lis kev cai.Thaum cov vitamin D tsis muaj kev cuam tshuam rau aPL-mediated modulation ntawm angiogenic yam nyob rau hauv thawj trophoblast, nws ho inhibit LMWH-induced sFlt-1 tso tawm.LMWH ua ke nrog vitamin D tej zaum yuav muaj txiaj ntsig ntau dua li kev kho ib leeg los ntawm kev tiv thaiv aPL. -induced trophoblast o thiab thim rov qab LMWH-induced sFlt-1 secretion.
