Doxorubicin hydrochloride CAS: 25316-40-9 99% Txiv kab ntxwv-liab Crystalline hmoov
| Catalog Number | xwm 90367 |
| Khoom npe | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Molecular Formula | C27H29NO11 · HCl |
| Molecular Luj | 579.98 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 29419000 ib |
Khoom Specification
| DejCov ntsiab lus | ≤ 4.0% |
| pH | 4.0-5.5 |
| Solubility | Soluble nyob rau hauv: dej, methanol thiab isotonic NaCl (aq).Solubility tsis zoo nyob rau hauv chloroform thiab lwm yam organic solvents. |
| Yam khoom muaj feem | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Assay | 99% |
| Residual Solvents | Acetone thiab cawv: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| Lwm yam impurities | ≤ 0.5% |
| Tag nrho cov impurities | ≤ 2.0% |
| Crystallinity | Ua raws li USP |
| Qhov tshwm sim | Txiv kab ntxwv-liab Crystalline hmoov |
| Kev txheeb xyuas | HPLC |
Cov neeg mob uas muaj P-glycoprotein thiab HER2 / neu (HER2) receptor-overexpressing mob cancer mis feem ntau muaj cov txiaj ntsig tsis zoo.Txawm li cas los xij, tsis muaj cov kab mob qog noj ntshav ntawm lub mis muag uas yog HER2 / P-glycoprotein ob-zoo, uas txwv kev tshawb fawb hauv daim teb no.Peb tshaj tawm txog kev txhim kho thiab tus cwj pwm ntawm cov tshuaj tiv thaiv kab mob los ntawm HER2-zoo mis. kab mob qog noj ntshav los ntawm kev hloov pauv ruaj khov ntawm ATP-binding cassette (ABC) subfamily B tus tswv cuab 1 (ABCB1) cov noob uas encodes P-glycoprotein.ABCB1 cov noob qhia cov qib siab dua tom qab hloov pauv, uas ua rau nce 40-fold hauv P-glycoprotein. kev qhia.Interestingly, kev hloov pauv ntawm ABCB1 kuj tau ua rau nce me ntsis hauv HER2 noob thiab qib qhia protein.Kev hloov pauv ntawm ABCB1 nce qib P-glycoprotein qhia ntau ntau.Cov qauv siv ntawm no los tsim cov kab ntawm tes no tsim nyog rau kev ceev, ruaj khov induction ntawm P-glycoprotein-mediated tshuaj tiv thaiv piv rau tr ntxiv txoj kev.Qhov kev ntsuam xyuas hauv vitro cytotoxicity qhia tau hais tias cov kab ntawm tes no muaj kev tiv thaiv kab mob rau ntau yam tshuaj tua kab mob.
