Direct Blue Cas: 314-13-6
| Catalog Number | xwm 90533 |
| Khoom npe | Direct Blue |
| CAS | 314-13-6 : kuv |
| Molecular Formula | C34H24N6Na4O14S4 |
| Molecular Luj | 960.81 ib |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 32129000 ib |
Khoom Specification
| Qhov tshwm sim | Cov hmoov dub |
| Assay | 99% |
| Poob rau ziab | 10% max |
| Solubility ntawm 0.1% hauv dej | Clear xiav daws |
| Wavelenght ntawm max absorption | 605-613 nm |
| Kev nqus tshwj xeeb (E1% / 1cm) | 800 min |
Vascular hyperpermeability ua rau muaj kev mob tshwm sim hauv o.Cov txheej txheem tam sim no rau hauv vivo kev ntsuam xyuas ntawm permeability raws li extravasation ntawm Evans Blue (EB)-bound albumin yog cumbersome thiab feem ntau tsis muaj rhiab heev.Peb tau tsim ib qho tshiab infrared fluorescence (IRF) txoj kev rau kev ntsuas ntawm EB-albumin extravasation kom muaj nuj nqis vascular permeability hauv murine qauv.Vascular permeability induced los ntawm endotoxaemia raug tshuaj xyuas rau tag nrho cov khoom nruab nrog cev, hlwb, daim tawv nqaij thiab peritoneum los ntawm IRF thiab cov tsoos absorbance-raws li ntsuas ntawm EB hauv cov ntaub so ntswg rho tawm.Organ IRF tau nce linearly nrog kev nce ntxiv ntawm cov hlab ntsha EB (2.5-25 mg / kg).Cov ntaub so ntswg IRF tau rhiab heev rau EB txuam nrog piv rau cov txheej txheem absorbance.Raws li, qhov sib txawv ntawm vascular permeability thiab lub cev EB tsub zuj zuj ntawm lipopolysaccharide-kho thiab saline-kho nas feem ntau tseem ceeb thaum soj ntsuam los ntawm IRF-raws li kev tshawb nrhiav tab sis tsis yog los ntawm kev nqus-raws li kev tshawb nrhiav.EB tau kuaj pom nyob rau hauv tag nrho 353 lub cev tau tshuaj xyuas nrog IRF tab sis tsuas yog hauv 67% (239/353) ntawm cov kabmob uas tau soj ntsuam los ntawm kev nqus-raws li txoj kev, ua kom pom kev txhim kho rhiab heev ntawm EB nrhiav pom hauv nruab nrog cev nrog IRF.Hauv qhov sib piv, EB hauv ntshav tom qab EB kev tswj hwm tau yooj yim ntsuas los ntawm ob txoj hauv kev nrog kev sib raug zoo ntawm ob txoj kev (n = 116, r2 = 0.86).Kev suav ntawm cov khoom nruab nrog cev tshwj xeeb EB-IRF qhov sib txawv vim endotoxin yog qhov zoo tshaj plaws thaum IRF tau muab piv nrog cov nas sib npaug rau qhov hnyav, poj niam txiv neej, thiab hnub nyoog, thiab nrog kev kho kom tsim nyog rau lub cev hnyav thiab EB plasma concentrations.Qhov tseem ceeb, EB-IRF txheej txheem tawm hauv lub cev tsis zoo rau cov keeb kwm yav dhau los.Hauv cov ntsiab lus, EB-IRF yog ib qho tshiab, rhiab heev, ceev, thiab yooj yim txoj kev rau cov txheeb ze kom muaj nuj nqis ntawm EB nyob rau hauv lub cev tsis zoo ntawm kev kho mob tiv thaiv nas.
