Diethylene triamine pentaacetic acid CAS: 67-43-6 99% Dawb crystalline hmoov
| Catalog Number | xwm 90220 |
| Khoom npe | Diethylene triamine pentaacetic acid |
| CAS | 67-43-6 |
| Molecular Formula | C14H23N3O10 |
| Molecular Luj | 393.3465 ib |
| Cov ntaub ntawv khaws cia | Ambient |
| Harmonized tariff Code | 29224985 ib |
Khoom Specification
| Cov hlau hnyav | 0.001% max |
| pH | 2 - 3 |
| Fe | 0.001% max |
| Solubility | Sparingly soluble hauv dej, 15% tov yog soluble hauv dej kub.Soluble nyob rau hauv tag nrho cov Alkali |
| Assay | 99% min |
| Sulfated tshauv | 0.1% max |
| Cl | 0.1% max |
| Qhov tshwm sim | Dawb crystalline hmoov |
Kev nce oxidative kev ntxhov siab nyob rau hauv cov xwm txheej hyperglycemic, los ntawm kev sib cuam tshuam ntawm AGEs nrog RAGE receptors thiab los ntawm kev ua kom muaj interleukin mediated transcription signalling, tau tshaj tawm hauv kev mob qog noj ntshav.Kev hloov pauv cov protein tau raug tshawb nrhiav rau lawv lub luag haujlwm hauv kev txhim kho thiab kev mob qog noj ntshav thiab autoantibody teb tawm tsam lawv tau txais kev txaus siab raws li kev sojntsuam rau kev kuaj pom tus kabmob ntxov.Txoj kev tshawb no tau txheeb xyuas cov kev hloov pauv hauv histone H1 thaum hloov kho los ntawm methylglyoxal (MG) thiab nws qhov cuam tshuam hauv auto-immunopathogenesis ntawm mob qog noj ntshav.Hloov kho histone pom cov kev hloov pauv hauv cov ntxhiab tsw qab, hloov tyrosine microenvironment, kev sib txuas ntawm cov kab sib txuas thiab tiam ntawm AGEs.Nws tau pom qhov npog ntsej muag ntawm thaj chaw hydrophobic thiab hypsochromic hloov pauv hauv ANS tshwj xeeb fluorescence.MG aggressively oxidized histone H1 ua rau tsub zuj zuj ntawm reactive carbonyls.Far UV CD ntsuas pom di-carbonyl induced li ntawm alpha qauv thiab th e induction ntawm beta daim ntawv conformation;thiab thermal denaturation (Tm) cov kev tshawb fawb tau lees paub qhov thermal stability ntawm cov hloov histone.FTIR tsom xam pom nyob rau hauv kuv band hloov, tiam ntawm ib pawg carboxyethyl thiab N-Cα vibrations nyob rau hauv lub hloov histone.Kev tshuaj xyuas LCMS tau lees paub qhov tsim ntawm Nε-(carboxyethyl) lysine thiab electron microscopic kev tshawb fawb qhia txog kev tsim cov amorphous aggregate.Hloov kho histone pom tau tias hloov pauv kev sib koom tes nrog DNA.Hloov H1 induced high titre antibodies nyob rau hauv luav thiab cov IgG cais daim ntawv sera ntawm luav txhaj tshuaj nrog hloov H1 qhia tshwj xeeb khi nrog nws cov tshuaj tiv thaiv nyob rau hauv Western Blot tsom xam.IgG cais tawm los ntawm sera ntawm cov neeg mob ntsws cancer, mob qog noj ntshav prostate, mob qog noj ntshav mis thiab mob qog noj ntshav ntawm lub taub hau thiab caj dab thaj tsam tau pom zoo pom zoo rau cov neo-epitopes ntawm cov hloov histone, qhia txog qhov muaj cov autoantibodies nyob rau hauv cov qog nqaij hlav.Txij li cov ntawv ceeb toom qhia txog kev sib txuas ntawm AGE-RAGE axis thiab carcinogenesis, glycoxidation ntawm histone H1 thiab nws cov immunogenicity paves txoj kev rau kev nkag siab lub luag hauj lwm ntawm glycoxidative puas nuclear proteins nyob rau hauv mob cancer.
