Cov nas tsuag tau muab tshuaj ib zaug ntawm cov nroj tsuag keeb kwm phenolic antioxidant Quercetin (QC) dawb, liposome encapsulated thiab galactosylated liposome encapsulated cov ntaub ntawv 2 h ua ntej hepatotoxic koob tshuaj carbontetrachloride (CCl4, 40% v / v hauv cov roj txiv roj, 1 ml / kg b. .wt).Ntawm peb cov ntawv sib txawv ntawm QC kuaj, tsuas yog galactosylated liposomal QC muab kev tiv thaiv tseem ceeb tiv thaiv CCl4 induced hepatic oxidative puas.Tom qab 24 teev ntawm kev txhaj tshuaj (SC) cov kab mob siab ntawm nas tau pom muaj qhov cuam tshuam rau CCl4 ua rau oxidative puas tsuaj thiab nws tau saib xyuas los ntawm qhov nce ntawm conjugated diene hauv daim siab.Qhov ob-fold nce hauv conjugated diene los ntawm induction ntawm CCl4 tau txo qis mus rau theem ib txwm los ntawm galactosylated liposomal QC ua ntej kho.Carbontetrachloride induced membrane puas nyob rau hauv cov kab mob siab thiab nws tau txiav txim los ntawm cov ntshav cov ntshav thiab cov ntaub so ntswg ntawm daim siab histopathological kuaj.Membrane kev puas tsuaj los ntawm induction ntawm CCl4 tau soj ntsuam ntxiv los ntawm qhov txo qis ntawm plasma membrane (PM) khi enzyme Na + / K + ATPase kev ua haujlwm thiab nws tsuas yog nce los ntawm kev kho ua ntej ntawm galactosylated liposomal QC.Carbontetrachloride induced ib tug ntau ntawm txo nyob rau hauv enzymatic thiab molecular endogenous antioxidant theem nyob rau hauv hepatic hlwb.Qhov kev nyuaj siab nyob rau hauv antioxidant system nyob rau hauv lub siab hlwb yog kiag li tiv thaiv tag nrho los ntawm ib koob ntawm galactosylated lipsosomal QC ua ntej CCl4 kev kho mob.Kev noj qab haus huv ntawm QC tau kwv yees tom qab 2 teev ntawm kev txhaj tshuaj flavonoid (8.9 micromol / kg lub cev hnyav) (dawb lossis liposomal daim ntawv) thiab 85% ntawm QC txhaj tshuaj tau pom nyob rau hauv daim siab nyob rau hauv cov ntaub ntawv ntawm galactosylated liposomal QC.Thaum tsuas yog 25% ntawm cov tshuaj txhaj tshuaj tau kuaj pom hauv daim siab thaum tus nqi zoo ib yam ntawm QC pub dawb raug txhaj.Carbontetrachloride kuj ua rau muaj kev hloov pauv hauv daim nyias nyias thiab nws tau soj ntsuam los ntawm kev txo qis hauv daim nyias nyias micro-viscosity.Kev kho dawb QC ua ntej ua rau tsis muaj kev tiv thaiv CCl4 induced nce hauv hepatic membrane fluidity, whereas galactosylated liposomal QC exerted ib qho tseem ceeb tiv thaiv kev nce.Cov txiaj ntsig ntawm txoj kev tshawb fawb no tau qhia tias QC hauv galactosylated liposome tuaj yeem tiv thaiv kev tiv thaiv tseem ceeb ntawm CCl4 induced hepatocellular raug mob.
