Cov khoom

Cov compound 4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone hydrochloride yog ib daim ntawv tshwj xeeb ntawm cov tshuaj tau piav qhia hauv cov lus teb dhau los, qhov twg nws nyob hauv daim ntawv ntawm hydrochloride ntsev.Daim ntawv hydrochloride ntsev feem ntau yog siv rau hauv kev siv tshuaj vim nws txhim khu kev ruaj ntseg, solubility, thiab yooj yim ntawm formulation.Qhov kev sib xyaw tshwj xeeb no muaj ntau yam qauv nthuav dav uas ua rau nws muaj txiaj ntsig zoo rau kev siv tshuaj.Lub xub ntiag ntawm pawg oxazolidinyl thiab morpholinone qhia tau tias muaj peev xwm cuam tshuam nrog cov hom phiaj lom neeg tshwj xeeb, ua rau nws muaj txiaj ntsig zoo hauv kev tshawb nrhiav thiab kev loj hlob ntawm cov tshuaj.Cov oxazolidinyl pawg tuaj yeem pom muaj nyob rau hauv ntau yam tshuaj tua kab mob thiab paub txog nws cov haujlwm tiv thaiv kab mob tshuaj tiv thaiv kab mob.Cov tshuaj no tuaj yeem pab kov yeej qhov nce ntawm cov tshuaj tiv thaiv kab mob los ntawm kev tsom cov kab mob uas tsis yooj yim rau kev kho.The morpholinone moiety, ntawm qhov tod tes, tau siv dav hauv tshuaj chemistry vim nws muaj peev xwm cuam tshuam nrog cov hom phiaj lom neeg.Lub xub ntiag ntawm cov aminomethyl pawg ntawm morpholinone qhia txog qhov muaj peev xwm rau kev sib cuam tshuam ntxiv thiab tshwj xeeb hauv kev khi rau lub hom phiaj.Xav txog cov qauv sib xyaw, nws yuav muaj cov ntawv thov ua cov tshuaj tua kab mob lossis tshuaj tua kab mob.Kev tshawb fawb ntxiv yog yuav tsum tau ua kom paub tseeb tias nws cov txheej txheem tshwj xeeb ntawm kev nqis tes ua thiab lub hom phiaj muaj peev xwm.Tsis tas li ntawd, lub compound lub pharmacokinetic thiab toxicological zog yuav tsum raug soj ntsuam los txiav txim nws cov kev ua tau zoo thiab kev nyab xeeb profiles.Formulated raws li ib tug hydrochloride ntsev, lub compound lub solubility yog txhim khu kev qha, ua rau nws zoo dua rau kev tswj qhov ncauj.Daim ntawv ntsev kuj tso cai rau kev yooj yim formulation rau hauv cov ntaub ntawv ntau npaum li cov ntsiav tshuaj los yog ntsiav tshuaj.Nyob rau hauv cov ntsiab lus, cov compound 4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3- morpholinone hydrochloride qhia tau hais tias muaj peev xwm nyob rau hauv cov tshuaj, tshwj xeeb tshaj yog raws li ib tug antibacterial los yog antimicrobial neeg sawv cev.Nws cov yam ntxwv nta thiab hydrochloride ntsev daim ntawv ua rau nws ib tug txaus nyiam neeg sib tw rau kev tshawb fawb thiab kev loj hlob ntxiv.Txawm li cas los xij, cov kev tshawb fawb ntxiv yog tsim nyog los txiav txim siab nws cov kev siv tshwj xeeb, cov txheej txheem ntawm kev ua, thiab kev nyab xeeb thiab kev ua tau zoo ua ntej nws tuaj yeem siv los ua tus neeg sawv cev kho mob.