Cov khoom

Cov tshuaj 2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1, 3(2H)-dione yog ib qho nyuaj organic molecule uas muaj peev xwm siv nyob rau hauv cov teb ntawm cov tshuaj thiab kws tshuaj.Lub xub ntiag ntawm lub isoindole core qhia tau hais tias cov compound no muaj cov yam ntxwv nta uas muaj kev lom zem thiab tau pom nyob rau hauv bioactive molecules.Isoindole derivatives tau raug tshaj tawm tias muaj ntau yam khoom siv tshuaj, suav nrog tshuaj tua kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj tua kab mob.Cov oxazolidinone moiety, sawv cev los ntawm pawg 1,3-oxazolidin-5-yl, paub txog nws cov tshuaj tua kab mob.Oxazolidinones tau siv los ua cov khoom tseem ceeb hauv cov tshuaj tua kab mob, tshwj xeeb tshaj yog tiv thaiv cov kab mob tiv thaiv kab mob.Qhov no qhia tau hais tias cov compound tej zaum yuav muaj peev xwm ua ib tug antibacterial neeg sawv cev.Lub xub ntiag ntawm morpholinone moiety, sawv cev los ntawm 4-(3-oxomorpholin-4-yl) phenyl pawg, ntxiv complexity rau lub compound lub peev xwm siv.Morpholines tau dav siv rau hauv cov tshuaj sib txuas vim lawv muaj peev xwm cuam tshuam nrog ntau lub hom phiaj lom neeg.Cov pab pawg oxo ntawm morpholinone tuaj yeem txhim kho qhov sib xyaw ua ke nrog cov hom phiaj tshwj xeeb, ua rau nws muaj txiaj ntsig zoo hauv kev tshawb nrhiav tshuaj thiab kev loj hlob.The 2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]- 1,3-oxazolidin-5-yl pawg, txuas rau isoindole core, tsim lub ntsiab active site ntawm cov compound.Cov pab pawg no cov qauv tshuaj tshwj xeeb qhia tau hais tias nws yuav muaj kev cuam tshuam nrog lub hom phiaj lom neeg xws li enzymes lossis receptors.Zuag qhia tag nrho, raws li cov khoom sib xyaw ua ke, nws muaj peev xwm nthuav tawm cov tshuaj pharmacological hauv cov tshuaj tua kab mob, tiv thaiv kab mob, thiab muaj peev xwm kho tau lwm qhov chaw.Txawm li cas los xij, nws cov kev siv tshwj xeeb thiab cov txheej txheem ntawm kev ua haujlwm yuav tsum tau txiav txim siab los ntawm kev tshawb fawb ntxiv, suav nrog hauv vitro thiab hauv vivo kev sim, txhawm rau ntsuas nws cov txiaj ntsig thiab kev nyab xeeb profiles. -3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione qhia cov lus cog tseg hauv thaj chaw tshuaj thiab pharmaceuticals vim nws cov qauv complex thiab muaj peev xwm pharmacological zog.Kev tshawb fawb yav tom ntej yog tsim nyog los tshawb txog nws cov kev siv tshwj xeeb, kev siv tshuaj kho tau zoo, thiab kev ua tau zoo tag nrho.