2′-Deoxyuridine CAS: 951-78-0
| Catalog Number | xwm 90583 |
| Khoom npe | 2'-Deoxyuridine |
| CAS | 951-78-0 : kuv |
| Molecular Formula | C9H12N2O5 |
| Molecular Luj | 228.20 Nws |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 293499 0 |
Khoom Specification
| Qhov tshwm sim | Dawb mus rau dawb hmoov |
| Assay | 99% |
| Melting Point | 164-168 ° C |
| Poob rau ziab | <1.0% |
| Residue ntawm Ignition | <0.1% |
Txhim kho kev siv nitrogen hauv cov nyuj yog qhov tseem ceeb txhawm rau txhawm rau txhawm rau txhim kho cov nyuj khov.Raws li purines thiab pyrimidines (PP) ua ib feem tseem ceeb ntawm rumen nitrogen, kev nkag siab zoo dua ntawm kev nqus thiab cov metabolism hauv nruab nrab ntawm PP yog qhov tseem ceeb.Txoj haujlwm tam sim no piav qhia txog kev txhim kho thiab kev siv tau ntawm ib txoj kev rhiab thiab tshwj xeeb rau kev txiav txim siab ib txhij ntawm 20 purines (adenine, guanine, guanosine, inosine, 2'-deoxyguanosine, 2'-deoxyinosine, xanthine, hypoxanthine), pyrimidines (cytosine, uracil, cytidine, uridine, thymidine, 2'-deoxyuridine), thiab lawv cov khoom degradation (uric acid, allantoin, β-alanine, β-ureidopropionic acid, β-aminoisobutyric acid) hauv cov ntshav plasma ntawm cov nyuj mis nyuj.Kev ua haujlwm siab ua kua chromatography-raws li cov txheej txheem ua ke rau electrospray ionization tandem huab hwm coj spectrometry (LC-MS / MS) tau ua ke nrog cov qauv matrix-matched calibration thiab ruaj khov isotopically labeled reference compounds.T nws qhov kev soj ntsuam ntau tau ua ntej los ntawm cov txheej txheem ua ntej kho tshiab uas muaj ethanol nag lossis daus, pom, evaporation thiab rov tsim dua.Kev sib cais thiab kev tshawb pom thaum lub sij hawm LC-MS/MS tsom xam tau tshawb xyuas.Nws tau raug lees paub tias kev siv lub cav-calibration qauv es tsis yog cov qauv kev sib tw linear ua rau qis dua CV% thiab qhov tsis muaj qhov ntsuas ntsuas tau pom tias muaj kev txaus siab ntawm cov kab rov tav.Cov txheej txheem npog cov concentration ntau rau txhua cov metabolite raws li qhov tseeb hauv cov qauv, xws li guanine: 0.10-5.0 μmol / L, thiab allantoin: 120-500 μmol / L.CV% rau qhov kev xaiv ntau npaum li cas yog qis dua 25%.Cov txheej txheem muaj qhov rov ua tau zoo (CV% ≤ 25%) thiab qhov nruab nrab precision (CV% ≤ 25%) thiab kev rov zoo zoo (91-107%).Tag nrho cov metabolites pom tau tias muaj kev ruaj ntseg mus ntev thiab kev ruaj ntseg zoo nyob rau hauv-khiav (CV% ≤10%).Cov qib sib txawv ntawm cov teebmeem matrix tau pom hauv cov ntshav, zis thiab mis.Qhov kev txiav txim siab ntawm cov txheeb ze matrix tshwm sim tau qhia tias txoj kev tsim nyog rau yuav luag txhua qhov kev kuaj PP metabolites hauv cov ntshav los ntawm cov hlab ntsha thiab lub portal hepatic, hepatic thiab gastrosplenic veins thiab, nrog rau qee qhov kev zam, kuj rau lwm hom tsiaj xws li nqaij qaib, npua, mink, tib neeg thiab nas.
