Uridine-5′-diphosphoglucuronic acid trisodium ntsev CAS: 63700-19-6 Dawb hmoov
| Catalog Number | xwm 90382 |
| Khoom npe | Uridine-5'-diphosphoglucuronic acid trisodium ntsev |
| CAS | 63700-19-6 |
| Molecular Formula | C15H19N2O18P2Na3 |
| Molecular Luj | 646.20 ib |
| Cov ntaub ntawv khaws cia | <-4 °C |
Khoom Specification
| Assay | 99% |
| Qhov tshwm sim | Dawb hmoov |
Txoj kev tshawb fawb tam sim no tsom mus tshawb xyuas qhov cuam tshuam ntawm irinotecan toxicity los ntawm biotransformation ntawm glucoaurantio-obtusin rau aurantio-obtusin.Intraperitoneal kev tswj hwm (ip) ntawm 100 mg / kg aurantio-obtusin ua rau muaj kev phom sij ntau ntxiv ntawm irinotecan, tab sis kev tswj hwm ip ntawm 100 mg / kg glucoaurantio-obtusin pom tias tsis muaj kev cuam tshuam rau irinotecan's toxicity.Tsis tas li ntawd, cov txheej txheem tau piav qhia los ntawm kev txiav txim siab qhov muaj peev xwm inhibition ntawm glucoaurantio-obtusin thiab aurantio-obtusin ntawm glucuronidation metabolism ntawm SN-38 uas tau raug suav hais tias yog cov khoom lag luam tseem ceeb ua lub luag haujlwm rau toxicity ntawm irinotecan.Cov txiaj ntsig tau pom tias aurantio-obtusin tau pom muaj zog sib tw inhibition ntawm glucuronidation ntawm SN-38, tab sis tsis pom zoo inhibition muaj peev xwm ntawm glucoaurantio-obtusin rau SN-38 glucuronidation tau pom.Cov txiaj ntsig no tau pom tias biotransformation ntawm glucoaurantio-obtusin ntawm aurantio-obtusin tau nce cov tshuaj lom ntawm irinotecan los ntawm kev nce inhibition ntawm SN-38 glucuronidation.
