Tiamulin 98% Cas: 125-65-5
| Catalog Number | xwm 91893 |
| Khoom npe | Tus nqi 98% |
| CAS | 125-65-5 ib |
| Molecular Formula | C22H34O5 |
| Molecular Luj | 378.5 ib |
| Cov ntaub ntawv khaws cia | -20 ° C |
| Harmonized tariff Code | 2918199090 ib |
Khoom Specification
| Qhov tshwm sim | Dawb hmoov |
| Assay | 99% min |
| Melting point | 170-1710 C |
| alpha | D24 + 20 ° (c = 3 hauv abs ethanol) |
| Boiling point | 482.8 ± 45.0 ° C (Tshaj tawm) |
| ceev | 1.15 ± 0.1 g / cm3 (Tshaj tawm) |
| solubility | DMSO:> 10mg / mL (ua kom sov) |
| pka ua | 12.91 ± 0.10 (Kev kwv yees) |
| kev ua haujlwm kho qhov muag | [α] / D +30 txog +40 ° (c = 1; CH2Cl2) |
Pleuromutilin yog ib qho diterpene uas tsim los ntawm ntau hom basidomycete, tshwj xeeb tshaj yog cov genus Pleurotus, nrhiav tau nyob rau hauv 1951. Pleuromutilin yog ib qho muaj zog thiab xaiv cov tshuaj tua kab mob uas muaj zog tiv thaiv ntau yam kab mob Gram zoo, uas tsis muaj kev cuam tshuam rau cov tshuaj tua kab mob uas twb muaj lawm vim nws hom tshwj xeeb. ntawm kev ua.Pleuromutilin inhibits protein synthesis los ntawm kev khi rau domain V ntawm 23S rRNA thiab qhov no tau coj mus rau kev loj hlob ntawm ntau semi-synthetic analogues raws li tiam tshiab tshuaj tua kab mob, xws li tiamulin thiab retapamulin.
Pleuromutilins xws li tiamulin thiab valnemulin tau siv rau qee lub sijhawm hauv cov tshuaj kho tsiaj los kho tus kab mob swine.Tsis ntev los no, ib tug semisynthetic pleuromutilin, retapamulin, tau qhia raws li ib tug tshuaj pleev rau cov kab mob Gram-zoo nyob rau hauv tib neeg.Pleuromutilins inhibit peptidyl transferase kev ua ntawm cov kab mob 50S ribosomal subunit los ntawm kev khi rau A site.
