Cov khoom

PH sensors tau tsim los ntawm anodically electrodepositing iridium oxide films (AEIROFs) mus rau microelectrodes ntawm daim tawv nqaij thiab coated nrog poly (ethyleneimine) (PEI) rau txhua yam stability.Cov no qhia tau hais tias super-Nernstian teb rau pH ntawm pH 4.0 txog 7.7 hauv chloride-free phosphate tsis.Qhov saum npoo ntawm cov nti tau coated nrog fibronectin rau kev txuas ntawm porcine aortic endothelial hlwb (PAECs).Lub peev xwm ua haujlwm ntawm pH sensor rau kev saib xyuas cov kev hloov pauv hauv zos pH tau tshawb xyuas los ntawm kev txhawb nqa PAECs nrog thrombin.Peb cov txiaj ntsig tau pom tias thrombin induced mob extracellular acidification ntawm PAECs thiab dissolution ntawm fibronectin, ua rau lub zos pH txo.Kev siv PD98059, ib qho mitogen-activated protein kinase (MAPK) inhibitor, txo cov acidification ntawm cov cellular thiab nce pH hauv zos tau pom.Txoj kev tshawb no qhia tau hais tias peb cov pH sensors tuaj yeem pab txhawb kev tshawb nrhiav ntawm cov xovtooj ntawm tes rau kev txhawb nqa los ntawm kev saib xyuas lub sijhawm tiag tiag, kev hloov pH hauv zos ntawm cov hlwb txuas nrog cov sensors.