Cov khoom

Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino) pyridin-3-yl)piperazine-1-carboxylate yog ib qho chaw uas muaj peev xwm loj heev hauv tshuaj chemistry thiab kev tsim tshuaj.Nws cov qauv molecular complex qhia txog ntau yam kev siv tau.Qhov kev sib xyaw no muaj cov tub ntxhais piperazine-1-carboxylate, uas yog ib qho kev siv scaffold nyob rau hauv cov tshuaj chemistry vim nws ntau yam xwm thiab ntau yam ntawm cov hom phiaj muaj peev xwm.Lub xub ntiag ntawm piperazine moiety tso cai rau kev sib cuam tshuam nrog ntau yam receptors thiab enzymes, ua rau nws yog ib qho kev nthuav neeg sib tw rau kev txhim kho cov tshuaj tua kab mob.The 6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido [2,3-d] pyrimidin-2-yl pawg hauv cov qauv muab cov kev ua haujlwm tshuaj muaj peev xwm.Xws li pyrido [2,3-d] pyrimidine derivatives tau kawm dav dav rau lawv cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob.Cov pab pawg cyclopentyl thiab methyl pab txhawb rau lipophilicity ntawm cov compound, uas tuaj yeem txhim kho nws cov cellular permeability thiab bioavailability.Tert-butyl ester pab pawg muab kev ruaj ntseg rau cov compound thiab tuaj yeem hloov mus rau lwm pawg ua haujlwm tau yooj yim, tso cai rau kev hloov kho ntxiv lossis derivatization.Qhov kev hloov pauv no muaj txiaj ntsig zoo hauv cov tshuaj chemistry, vim nws ua rau kev txhim kho ntau lub zog thiab xaiv cov khoom sib txuas.Cov pyridin-3-yl pawg hauv cov qauv ua raws li lub peev xwm ligand rau ntau yam receptors, xws li G protein-coupled receptors (GPCRs).Qhov no qhia tau hais tias cov compound yuav muaj kev cuam tshuam rau intracellular signaling pathways thiab tuaj yeem tshawb nrhiav ntxiv rau nws lub peev xwm ua tus modulator lossis antagonist ntawm cov receptors tshwj xeeb koom nrog cov kab mob.Cov qauv tag nrho ntawm tert-butyl 4-(6-((6-) (1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate tseem ceeb nws lub peev xwm hauv kev txhim kho cov kev kho tshiab.Nws muaj sijhawm los soj ntsuam enzyme inhibition, receptor binding, thiab kev hloov kho ntawm ntau yam kev lom neeg.Nrog rau kev tshawb nrhiav thiab kev ua kom zoo dua qub, cov khoom siv no tuaj yeem ua cov khoom siv lead ua rau kev txhim kho cov tshuaj tsom rau mob qog noj ntshav, mob, lossis lwm yam kab mob.Nws cov yam ntxwv tshwj xeeb thiab muaj peev xwm ua haujlwm lom neeg ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb ntxiv thiab kev loj hlob hauv thaj chaw tshuaj chemistry.In xaus, tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl- 5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate tuav cov lus cog tseg ua ntau yam sib xyaw rau kev tsim tshuaj.Nws cov qauv nyuaj thiab cov kev ua haujlwm tshuaj muaj peev xwm ua rau nws yog ib tus neeg sib tw txaus siab rau kev tshawb nrhiav ntxiv los ua tus neeg sawv cev kho mob rau ntau yam kab mob thiab mob.