Cov khoom

6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-ib hydrochloride yog ib tug compound nrog rau cov ntawv thov hauv kev tshawb fawb tshuaj thiab kev tsim tshuaj.Nws cov qauv molecular tshwj xeeb muab lub sijhawm rau kev tshawb nrhiav rau nws txoj kev siv tshuaj kho mob.Cov tshuaj no belongs rau pyrido [2,3-d] pyrimidinone tsev neeg, uas tau kawm dav dav rau nws cov haujlwm tshuaj.Lub xub ntiag ntawm pawg acetyl qhia tias muaj peev xwm cuam tshuam nrog cov enzymes koom nrog hauv cov txheej txheem ntawm tes.Nws tuaj yeem muaj kev cuam tshuam rau cov enzymes xws li kinases lossis proteases, ua rau nws yog ib tus neeg sib tw rau kev txhim kho cov enzyme tshwj xeeb inhibitors.Cov pawg cyclopentyl thiab methyl hauv cov qauv ua rau cov khoom sib xyaw lipophilic xwm.Cov cuab yeej no tso cai rau nws yooj yim hla cov kab mob lom neeg, ua rau nws muaj peev xwm ua tus neeg sib tw tshuaj.Tej zaum nws yuav muaj kev txhim kho permeability thiab bioavailability, ua rau nws tsim nyog rau kev tswj qhov ncauj thiab kev faib khoom system.The 1-piperazinyl thiab 2-pyridinyl pawg tam sim no nyob rau hauv lub compound muab versatility rau nws muaj peev xwm siv nyob rau hauv cov tshuaj tsim.Piperazine derivatives tau pom dav dav hauv tshuaj chemistry rau lawv cov dej num lom neeg.Cov pab pawg piperazine tuaj yeem pab txhawb rau receptor binding thiab modulate pharmacokinetic zog.Ntxiv mus, pawg pyridine feem ntau koom nrog ligand-receptor kev sib cuam tshuam, raws li pyridine nplhaib tshuab tuaj yeem tsim cov ntawv cog lus hydrogen nrog cov chaw receptor tshwj xeeb.Cov khoom no ua rau cov khoom sib xyaw no ua rau muaj peev xwm ligand rau ntau yam receptors, suav nrog G protein-coupled receptors.Xav txog cov pyrido[2,3-d] pyrimidinone scaffold thiab muaj cov pab pawg piperazine, cov compound tuaj yeem tshawb xyuas los ntawm cov tshuaj tiv thaiv kab mob cancer. .Nws tuaj yeem pom cov teebmeem cytotoxic tawm tsam cov qog nqaij hlav cancer los ntawm inhibition ntawm cov kev qhia tshwj xeeb uas cuam tshuam nrog kev loj hlob ntawm tes.Cov kev tshawb fawb ntxiv uas muaj nyob rau hauv vitro thiab hauv vivo qauv tuaj yeem soj ntsuam nws lub peev xwm los ua tus neeg sawv cev tiv thaiv qog. Tsis tas li ntawd, cov tshuaj pyrido[2,3-d] pyrimidinone core tuaj yeem hloov kho rau cov kab mob tshwj xeeb lossis cov xwm txheej.Los ntawm kev qhia cov pab pawg ua haujlwm tsim nyog lossis cov neeg hloov pauv, nws cov kev xaiv thiab lub zog tuaj yeem txhim kho, tso cai rau kev txhim kho ntawm cov tshuaj kho mob tshwj xeeb. piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-ib hydrochloride tuav tau ntau qhov chaw ntawm kev tshawb fawb tshuaj.Nws cov yam ntxwv nta tso cai rau kev tshawb nrhiav hauv enzyme inhibition, receptor khi, thiab kev tiv thaiv kab mob cancer.Kev tshawb nrhiav ntxiv thiab kev ua kom zoo dua ntawm nws cov qauv tseem ceeb yuav ua rau cov neeg sib tw tshuaj tshiab nrog kev txhim kho kev ua tau zoo thiab tshwj xeeb rau ntau lub hom phiaj kho mob.