Cov khoom

Telithromycin tau pib ua thawj zaug hauv lub teb chaws Yelemees raws li kev kho qhov ncauj ib hnub rau cov kab mob ua pa nrog rau kev mob ntsws hauv zej zog, cov kab mob ua rau mob ntsws ntev, mob sinusitis thiab tonsillitis / pharyngitis.Qhov no semisynthetic derivative ntawm lub ntuj macrolide erythromycin yog thawj lub khw muag khoom ketolides, chav kawm tshiab ntawm cov tshuaj tua kab mob uas muaj C3-ketone es tsis yog pawg L-cladinose.Lub nplhaib 14-tus neeg ua haujlwm tiv thaiv kab mob tiv thaiv kab mob cov kab mob sib txuas los ntawm kev khi rau ob qhov ntawm 50S subunit ntawm cov kab mob ribosomes.Nws qhia tau hais tias muaj zog hauv vitro ua haujlwm tawm tsam cov kab mob ua pa xws li Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis thiab Streptococcus pyogenes nrog rau lwm yam kab mob atypical.Cov pab pawg 3-keto confers acidic stability thiab txo induction ntawm macrolide-lincosamide-streptogramin B tsis kam uas nquag pom nrog macrolides.Qhov hloov pauv C11-C12 carbamate residue zoo nkaus li tsis tsuas yog ua kom muaj kev sib raug zoo rau ribosomal binding site tab sis kuj ua kom ruaj khov ntawm cov tshuaj tiv thaiv esterase hydrolysis thiab zam kev tsis kam vim kev tshem tawm cov macrolides ntawm lub xov tooj ntawm tes los ntawm lub twj tso kua mis efflux encoded los ntawm mef noob hauv qee yam kab mob. .Telithromycin yog ob qho tib si kev sib tw inhibitor thiab substrate ntawm CYP3A4.Txawm li cas los xij, tsis zoo li ob peb macrolides xws li troleandomycin, nws tsis tsim ib qho kev ruaj ntseg inhibitory CYP P-450 Fe2+-nitrosoalkane metabolite complex uas muaj peev xwm ua rau hepatotoxic.Cov tshuaj no zam tau zoo thiab muab faib rau hauv cov ntaub so ntswg pulmonary, bronchial secretions, tonsils thiab qaub ncaug.Nws hloov tawm los ua kom nquag plias hauv azurophil granules ntawm polymorphonuclear neutrophils li no yooj yim nws xa mus rau cov kab mob phagocytosed.