Streptozocin CAS: 18883-66-4 Pleev daj crystalline hmoov
Catalog Number | xwm 90359 |
Khoom npe | tshuaj streptozocin |
CAS | 18883-66-4 |
Molecular Formula | C8H15N3O7 |
Molecular Luj | 265.22 Nws |
Cov ntaub ntawv khaws cia | -20 ° C |
Harmonized tariff Code | 29419090 ib |
Khoom Specification
Assay | 99% |
Qhov tshwm sim | daj ntseg daj crystalline hmoov |
Mob ntshav qab zib mellitus muaj feem cuam tshuam rau qib qis qis qis thiab mob oxidative kev nyuaj siab.Bupleurum Polysaccharides (BPs), cais los ntawm Bupleurum smithii var.parvifolium muaj cov tshuaj tiv thaiv kab mob thiab tiv thaiv oxidative.Txawm li cas los xij, me ntsis paub txog nws txoj kev kho mob rau ntshav qab zib.Hauv qhov kev sim no, qhov cuam tshuam ntawm BPs ntawm kev txo qis ntshav qab zib thiab cov txheej txheem hauv qab tau tshawb xyuas.Cov qauv nas ntshav qab zib tau tsim los ntawm kev txhaj tshuaj intraperitoneal txuas ntxiv ntawm streptozotocin (100 mg / kg lub cev hnyav) rau ob hnub.Cov nas uas muaj ntshav qabzib ntau dua 16.8 mmol / L raug xaiv rau kev sim.Cov nas uas muaj ntshav qab zib tau noj cov tshuaj BPs (30 thiab 60 mg / kg) ib hnub ib zaug rau 35 hnub.BPs tsis tsuas yog txo qis cov piam thaj hauv cov ntshav, tab sis kuj nce cov ntshav qab zib insulin thiab lub siab glycogen hauv cov nas ntshav qab zib piv rau cov qauv nas.Tsis tas li ntawd, BPs kev tswj hwm tau txhim kho cov lus qhia insulin thiab txo qis apoptosis hauv pancreas ntawm cov nas mob ntshav qab zib.Cov kev soj ntsuam histopathological ntxiv tau pom tias BPs tiv thaiv kab mob pancreas thiab daim siab los ntawm oxidative thiab inflammatory puas.Cov txiaj ntsig no qhia tias BPs tiv thaiv kab mob pancreatic β hlwb thiab daim siab hepatocytes thiab ameliorate ntshav qab zib, uas cuam tshuam nrog nws cov tshuaj tiv thaiv oxidative thiab tiv thaiv kab mob.