Polymyxin B sulfate CAS: 1405-20-5 Dawb hmoov
| Catalog Number | xwm 90360 |
| Khoom npe | Polymyxin B sulfate |
| CAS | 1405-20-5 : kuv |
| Molecular Formula | C55H96N16O13 · 2H2SO4 |
| Molecular Luj | 1385.61 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 29419000 ib |
Khoom Specification
| Xaus | Ua raws li USP35 |
| Cov hlau hnyav | <20 ppm |
| pH | 5-7 |
| Kev txheeb xyuas | Ua kua chromatography: conforms |
| Assay | 99% |
| Qhov tshwm sim | Dawb hmoov |
| Poob rau ziab | <6% |
| Solubility | Dawb soluble hauv dej, me ntsis soluble hauv Ethanol |
| Sulfate | 15.5% - 17.5% |
| Particle Loj | <30µm |
| Kev sib hloov kho qhov muag tshwj xeeb | -78 ° -90 ° |
| Phenylalanine | 9.0% -12.0% |
| Pyrogens | Ua tau raws li qhov yuav tsum tau ua |
| Sulfated tshauv | <0.75% |
| Tag nrho cov suav aerobic | <100cfu/g |
| Muaj peev xwm | > 6500 IU/mg |
Lub ExPortal protein secretion organelle hauv Streptococcus pyogenes yog ib qho anionic phospholipid-muaj membrane microdomain enriched hauv Sec translocons thiab postsecretion protein biogenesis yam.Polymyxin B khi rau thiab cuam tshuam rau ExPortal kev ncaj ncees, ua rau muaj qhov tsis xws luag ntawm ntau cov co toxins.Txhawm rau kom nkag siab txog yam tseem ceeb uas cuam tshuam rau ExPortal lub koom haum, ib qho tshuaj ntsuam genetic screen tau ua los xaiv rau qhov tshwm sim ntawm polymyxin B-resistant mutants uas qhia txog ExPortal kev ncaj ncees.Tag nrho-genome resequencing ntawm 25 resistant mutants qhia los ntawm ib tug mus rau plaub kev hloov ntawm ib mutant genome pawg feem ntau nyob rau hauv ib tug tseem ceeb txheej ntawm 10 pawg noob.Kev tsim kho ntawm cov mutants nrog ib tus neeg tshem tawm lossis kev tso tawm pom tau tias 7 cov noob caj noob ces confer kuj thiab txhim kho ExPortal kev ncaj ncees los ntawm kev ua haujlwm tsis zoo, thaum 3 feem ntau yog vim muaj kev ua haujlwm thiab / lossis kev sib xyaw ua ke.Cov noob caj noob ces muaj xws li kev hloov pauv ntawm lipid biosynthesis, ntau cov noob koom nrog hauv kev tau txais cov zaub mov, thiab ntau yam noob koom nrog hauv cov lus teb kev ntxhov siab.Ob tug tswv cuab ntawm chav kawm tom kawg kuj ua haujlwm raws li cov tswj hwm tshiab ntawm SpeB cysteine protease zais cia.Kev soj ntsuam ntawm kev hloov pauv feem ntau, ib qho kev tshem tawm ib qho nucleotide nyob rau hauv ib qho kev sib law liag ntawm 9 qhov sib law liag adenine nyob rau hauv pstS, encoding ib feem ntawm high-affinity Pi transporter, qhia tias cov kab ke no ua haujlwm raws li kev hloov pauv molecular los pab txhawb kev hloov pauv kev ntxhov siab.Ua ke, cov ntaub ntawv no qhia txog qhov muaj nyob ntawm daim nyias nyias cov lus teb uas txhawb nqa ExPortal kev ncaj ncees thiab tsis kam mus rau cationic antimicrobial peptides.
