Spiramycin Cas: 8025-81-8
| Catalog Number | xwm 90452 |
| Khoom npe | Spiramycin |
| CAS | 8025-81-8 |
| Molecular Formula | C43H74N2O14 |
| Molecular Luj | 843.05 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 29419000 ib |
Khoom Specification
| Qhov tshwm sim | Dawb hmoov |
| Assay | > 4100 IU/mg |
| Cov hlau hnyav | <20 ppm |
| Poob rau ziab | <3.5% |
| Sulfated tshauv | <1.0% |
| Ethanol | <2.0% |
| Kev sib hloov kho qhov muag tshwj xeeb | -85 rau -80 deg |
Streptomyces ambofaciens synthesizes macrolide tshuaj tua kab mob spiramycin.Lub biosynthetic gene pawg rau spiramycin tau tshwm sim rau S. ambofaciens.Ntxiv rau qhov kev tswj hwm noob caj noob ces srmR (srm22), yav dhau los txheeb xyuas (M. Geistlich li al., Mol. Microbiol. 6: 2019-2029, 1992), peb qhov kev tswj hwm cov noob tau raug txheeb xyuas los ntawm kev soj ntsuam ua ntu zus.Kev txheeb xyuas cov noob caj noob ces thiab kev sim tshuaj tsis ua haujlwm tau pom tias tsuas yog ib qho ntawm peb cov noob no, srm40, ua lub luag haujlwm tseem ceeb hauv kev tswj hwm ntawm spiramycin biosynthesis.Kev cuam tshuam ntawm srm22 lossis srm40 tshem tawm spiramycin ntau lawm thaum lawv cov lus tshaj tawm nce spiramycin ntau lawm.Kev soj ntsuam kev nthuav qhia tau ua los ntawm kev thim rov qab-PCR (RT-PCR) rau tag nrho cov noob ntawm pawg hauv hom tsiaj qus thiab hauv srm22 (srmR) thiab srm40 deletion mutants.Cov txiaj ntsig tau los ntawm kev tshuaj ntsuam xyuas, ua ke nrog cov los ntawm cov kev sim ua kom tiav, qhia tias Srm22 yuav tsum muaj rau srm40 qhia, Srm40 yog ib txoj hauv kev tshwj xeeb activator uas tswj feem ntau, yog tias tsis yog tag nrho, ntawm spiramycin biosynthetic noob.
