Poly-L-lysine kua (0.1%) Cas: 25988-63-0
| Catalog Number | xwm 90306 |
| Khoom npe | Poly-L-lysine kua (0.1%) |
| CAS | 25988-63-0 |
| Molecular Formula | C18H38N6O4 |
| Molecular Luj | 402.532124042511 |
| Cov ntaub ntawv khaws cia | 2-8 ° C |
Khoom Specification
| Assay | 0.1% |
| Qhov tshwm sim | Cov kua dej tsis muaj xim |
eucine-nplua nuj rov kinase 2 (LRRK2) kev hloov pauv yog feem ntau paub ua rau Parkinson's disease (PD).Cov yam ntxwv kho mob ntawm LRRK2 PD yog qhov sib txawv ntawm idiopathic PD, nrog rau kev sib sau ntawm α-synuclein thiab / lossis tau thiab / lossis ubiquitin hauv intraneuronal aggregates.Qhov no qhia tias LRRK2 yog tus yuam sij rau kev nkag siab txog aetiology ntawm qhov teeb meem.Txawm hais tias poob-ntawm-kev ua haujlwm tsis tshwm sim los ua cov txheej txheem ua rau PD hauv cov neeg mob LRRK2, nws tsis paub meej tias cov protein no cuam tshuam li cas.Hauv txoj kev tshawb no, peb tshaj tawm tias LRRK2 overexpression nyob rau hauv hlwb thiab hauv vivo impairs cov kev ua ntawm ubiquitin-proteasome txoj kev, thiab hais tias qhov no suav nrog rau tsub zuj zuj ntawm ntau yam substrates nrog LRRK2 overexpression.Peb qhia tau hais tias qhov no tsis yog kho los ntawm LRRK2 aggregates loj lossis sequestration ntawm ubiquitin rau cov aggregates.Qhov tseem ceeb, xws li qhov txawv txav tsis pom nrog overexpression ntawm cov protein muaj feem xyuam LRRK1.Peb cov ntaub ntawv qhia tias LRRK2 inhibits kev tshem tawm ntawm proteasome substrate s upstream ntawm proteasome catalytic kev ua si, nyiam cov tsub zuj zuj ntawm cov proteins thiab aggregate tsim.Yog li, peb muab qhov sib txuas molecular ntawm LRRK2, feem ntau paub ua rau PD, thiab nws tau piav qhia yav dhau los phenotype ntawm cov protein ntau.
