Platinum ntawm activated carbon Cas: 7440-06-4
| Catalog Number | xwm 90696 |
| Khoom npe | Platinum ntawm activated carbon |
| CAS | 7440-06-4 : kuv |
| Molecular Formula | Pt |
| Molecular Luj | 195.08 Nws |
| Cov ntaub ntawv khaws cia | 2-8 ° C |
| Harmonized tariff Code | 28439000 ib |
Khoom Specification
| Qhov tshwm sim | silvery-grey meta |
| Assay | 99% |
| Dkev xav | 21.45 Nws |
| Melting point | 1772 ℃ |
| Boiling point | 3827 ℃ |
| Refractive Index | N20/D 1.347 |
| Flash point | 3825 ° C |
| Vapor siab | 0 mmHg (kwv yees) (NIOSH, 2016) |
Txhawm rau tshawb nrhiav cov tshiab platinum-raws li cov tshuaj tiv thaiv kab mob uas txawv ntawm cov qauv thiab kev sib cuam tshuam ntawm cov tshuaj cisplatin los ntawm kev tsim cov bifunctional intrastrand 1,2 GpG adduct, monofunctional platinum + DNA adducts nrog kev sib cuam tshuam uas tsis yog-covalent tau kawm.Nws tau tshaj tawm tias cov monofunctional testosterone-raws li platinum (II) cov neeg ua haujlwm nthuav tawm cov haujlwm anticancer siab.Ntxiv mus, nws kuj tau pom tias cov tshuaj testosterone-raws li platinum cov neeg ua haujlwm tuaj yeem ua rau DNA helix mus rau qhov tseem ceeb unwinding thiab khoov dua cov tsis-testosterone-based platinum agents.Txawm li cas los xij, cov txheej txheem kev sib cuam tshuam ntawm cov neeg ua hauj lwm platinum nrog DNA ntawm qib atomic tseem tsis tau paub meej txog tam sim no. Hauv kev ua haujlwm tam sim no, peb siv cov kev sim molecular dynamics (MD) thiab DNA conformational dynamics xam los kawm txog DNA distortion zog ntawm testosterone- raws li platinum + DNA, txhim kho testosterone-raws li platinum + DNA thiab tsis yog-testosterone-based platinum + DNA adducts.Cov txiaj ntsig tau pom tias kev sib cuam tshuam ntawm kev txhim kho hloov pauv hloov pauv testosterone-raws li tus neeg sawv cev platinum nrog DNA molecule tuaj yeem ua rau DNA loj dua qhov sib txawv dua li kev sib cuam tshuam ntawm lub ntsej muag ntawm cov tawv nqaij testosterone-raws li platinum tus neeg sawv cev nrog DNA molecule.Kev tshawb nrhiav ntxiv rau cov tsis-testosterone-raws li tus neeg sawv cev platinum qhia qhov tshwm sim ntawm qhov tsis tseem ceeb ntawm kev hloov pauv DNA vim tsis muaj testosterone ligand hauv tus neeg sawv cev zoo li no.Raws li kev txheeb xyuas DNA dynamics, DNA lub hauv paus kev taw qhia hais txog DNA groove parameter hloov pauv thiab hydrogen daim ntawv cog lus kev puas tsuaj ntawm DNA puag khub kuj tau tham hauv txoj haujlwm no.Qhov hloov pauv hloov pauv hauv kev txhim kho testosterone-based platinum tus neeg sawv cev ua rau muaj kev sib cuam tshuam nrog DNA hauv qhov txhim kho testosterone-raws li platinum + DNA adduct, uas yog qhov sib txawv ntawm qhov sib cuam tshuam ntawm lub ntsej muag tshwm sim los ntawm kev sib txuas tsis sib xws hauv tus neeg sawv cev ntawm testosterone-based platinum.Cov kev tshawb fawb tam sim no muab cov ntaub ntawv tseem ceeb ntawm DNA kev sib haum xeeb cuam tshuam los ntawm testosterone-based platinum complex ntawm atomic qib.
