Metronidazole Cas: 443-48-1
| Catalog Number | xwm 91888 |
| Khoom npe | Metronidazole |
| CAS | 443-48-1 : kuv |
| Molecular Formula | C6H9N3O3 |
| Molecular Luj | 171.15 Nws |
| Cov ntaub ntawv khaws cia | 2-8 ° C |
| Harmonized tariff Code | 29332990 ib |
Khoom Specification
| Qhov tshwm sim | Dawb crystalline hmoov |
| Assay | 99% min |
| Melting point | 159-161 ° C (lit.) |
| Boiling point | 301.12°C (kev kwv yees) |
| ceev | 1.3994 (zeeg) |
| Refractive Index | 1.5800 (kwv yees) |
| Fp | 9 ℃ |
| solubility | acetic acid: 0.1 M, ntshiab, faintly daj |
| pka ua | pKa 2.62 (H2O, t = 25 ± 0.2, tsis paub meej) |
| Dej Solubility | 0.1 g / 100 mL ntawm 20 ºC |
Metronidazole yog cov tshuaj xaiv rau amebiases, qhov chaw mos trichomoniasis thiab trichlomonadic urethritis nyob rau hauv cov txiv neej, lambliosis, amebic dysentery, thiab anaerobic kab mob tshwm sim los ntawm cov kab mob uas rhiab heev rau cov tshuaj.Lub ntsiab lus ntawm cov tshuaj no yog flagyl, protostat, trichopol, thiab vagimid.
Metronidazole muaj nyob rau hauv qhov ncauj, intravaginal, tshuaj pleev, thiab parenteral npaj.Nws yog tsim los ntawm ntau lub tuam txhab, tab sis tsuas yog muaj los ntawm kev sau ntawv.Kev tsis pom kev ib puag ncig yog qhov tsis zoo, thiab yog tias nws tshwm sim, nws tsis zoo li yuav ua rau muaj tshuaj lom.
Siv raws li ib tug antibacterial nyob rau hauv kev kho mob ntawm rosacea.Antiprotozoal (trichomonas).Muaj peev xwm tib neeg carcinogen.
Metronidazole, yog ib qho tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob.Nws yog tsuas yog siv los kho lossis tiv thaiv kab mob hauv zos los yog kab mob hauv zos uas tshwm sim los ntawm cov kab mob anaerobic, xws li kab mob anaerobic kab mob hauv plab kab noj hniav, plab zom mov, poj niam cev xeeb tub, qis ua pa, daim tawv nqaij thiab cov nqaij mos, pob txha thiab pob qij txha, thiab lwm yam. , kab mob meningeal, thiab colitis tshwm sim los ntawm kev siv tshuaj tua kab mob kuj zoo.Tetanus feem ntau kho nrog tetanus antitoxin (TAT).Nws kuj tseem siv tau rau qhov ncauj anaerobic kab mob.Thaum Lub Kaum Hli 27, 2017, cov npe ntawm cov kab mob carcinogens luam tawm los ntawm World Health Organization's International Agency for Research on Cancer tau raug txheeb xyuas ua ntej, thiab metronidazole tau suav nrog hauv cov npe 2B carcinogens.Thaum Lub Ib Hlis Ntuj xyoo 2020, metronidazole tau raug xaiv rau hauv pawg thib ob ntawm cov npe khoom lag luam hauv lub tebchaws.
Metronidazole yog tus neeg sawv cev zoo tshaj plaws muaj rau kev kho mob ntawm cov tib neeg uas muaj txhua hom mob amebiasis, tshwj tsis yog cov neeg uas muaj asymptomatic tab sis tseem ua rau cov hlwv.Qhov xwm txheej ntawd hu rau kev siv tshuaj intraluminal amebicide zoo, xws li diloxanide furoate, paromomycin sulfate, lossis diiodohydroxyquin.Metronidazole yog nquag tawm tsam plab hnyuv thiab extraintestinal cysts thiab trophozoites.
Txawm hais tias quinacrine hydrochloride tau siv los kho giardiasis, ntau tus kws kho mob nyiam metronidazole.Furazolidone yog lwm txoj kev xaiv.
Metronidazole yog cov tshuaj xaiv nyob rau hauv cov teb chaws Europe rau anaerobic kab mob;Kev txhawj xeeb txog kev muaj peev xwm carcinogenicity tau ua rau qee qhov kev ceeb toom hauv kev siv hauv Tebchaws Meskas. Tsis ntev los no nws tau pom tias muaj txiaj ntsig zoo hauv kev kho kab mob D. medinensis (Guinea worm) thiab Helicobacter pylori.
Nws kuj yog siv nyob rau hauv pob txuv rosacea, balantidiasis thiab Guinea kab mob kab mob.T. vaginalis kab mob resistant mus rau ib txwm noj yuav tsum tau kev kho mob tshwj xeeb.
