Cov khoom

1.Early T-cell precursor leukemia (ETP-ALL) yog ib qho kev pheej hmoo siab subtype ntawm tib neeg leukemia uas tsis to taub ntawm qib molecular.Ntawm no peb qhia txog kev hloov pauv mus rau lub hom phiaj zinc ntiv tes E-box-binding transcription factor ZEB2 raws li qhov tshwm sim ntawm caj ces tshwm sim hauv qhov tsis paub tab / ETP-ALL.Siv tus qauv ua kom tau txais txiaj ntsig-ntawm-ua haujlwm nas, peb pom tau tias kev txhawb nqa Zeb2 qhia pib T-cell leukemia.Ntxiv mus, Zeb2-tsav nas leukemia nthuav tawm qee yam ntawm tib neeg tsis paub tab / ETP-ALL gene qhia kos npe, nrog rau kev txhim kho leukemia-pib peev xwm thiab qhib Janus kinase (JAK) / cov cim hloov pauv thiab activators ntawm transcription (STAT) qhia los ntawm transcriptional activation ntawm IL7R.Txoj kev tshawb no nthuav tawm ZEB2 raws li ib qho oncogene nyob rau hauv biology ntawm tsis paub tab / ETP-ALL thiab paving txoj kev mus rau pre-clinical kev tshawb fawb ntawm tshiab tebchaw rau kev kho mob ntawm no aggressive subtype ntawm tib neeg T-ALL siv peb Zeb2-tsav nas qauv.

2.Pluripotency, kev rov ua dua tshiab rau tus kheej, thiab kev sib txawv yog cov yam ntxwv tshwj xeeb ntawm embryonic qia (ES) hlwb, yog li muab cov kev xav tseem ceeb hauv cov tshuaj regenerative.Cov txheej txheem kev loj hlob yuav tsum muaj lub koom haum kho kom zoo, feem ntau yog tswj hwm los ntawm JAK / STAT, PI3K / AKT, thiab ERK / MAPK txoj hauv kev.SPREDs (Sprouty ntsig txog cov proteins nrog EVH1 domain) tau tshawb pom raws li inhibitors ntawm ERK/MAPK signaling pathway, whereas tsis muaj dab tsi paub txog lawv cov dej num hauv ES hlwb thiab thaum ntxov sib txawv, kom deb li deb.Peb generated SPRED1 thiab SPRED2 overexpressing thiab SPRED2 knockout murine ES cov hlwb los txheeb xyuas cov haujlwm ntawm SPRED cov proteins hauv ES hlwb thiab thaum ntxov sib txawv.Kev nthuav tawm ntau dhau ntawm SPREDs ua rau muaj txiaj ntsig zoo rau tus kheej rov ua dua tshiab thiab clonogenicity ntawm murine ES hlwb, qhov tsis muaj SPRED2 txo qis kev loj hlob thiab nce apoptosis.Thaum ntxov sib txawv hauv lub cev embryoid, SPREDs txhawb lub xeev pluripotent thiab inhibit kev sib txawv uas yog mesodermal d ifferentiation rau hauv cardiomyocytes yog txiav txim siab ncua thiab inhibited.LIF- thiab kev loj hlob zoo-stimulation tau qhia tias SPREDs inhibit ERK / MAPK ua rau hauv murine ES hlwb.Txawm li cas los xij, tsis muaj qhov cuam tshuam los ntawm LIF-induced activation ntawm JAK / STAT3, lossis PI3K / AKT signaling txoj kev los ntawm SPRED proteins.Peb qhia tau hais tias SPREDs txhawb tus kheej-renewal thiab inhibit mesodermal sib txawv ntawm murine ES hlwb los ntawm kev xaiv suppression ntawm ERK / MAPK taw qhia txoj hauv kev hauv pluripotent hlwb.