Tom ntej: Iodonitrotetrazolium Chloride CAS: 146-68-9
| Catalog Number | xwm 90473 |
| Khoom npe | Iodonitrotetrazolium chloride yog siv |
| CAS | 146-68-9 |
| Molecular Formula | C19H13ClIN5O2 |
| Molecular Luj | 505.70 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 32129000 ib |
Khoom Specification
| Kev txheeb xyuas | H-NMR |
| Qhov tshwm sim | Lub teeb daj rau txiv kab ntxwv hmoov |
| Assay | > 99% |
| Solubility | Clear daws |
Interferon-induced transmembrane protein 1 (IFITM1) yog ib qho ntawm interferon-induced transmembrane protein cov neeg hauv tsev neeg.Hauv txoj kev tshawb no, peb tau tshaj tawm tias qhov kev nthuav qhia IFITM1 siab hauv tib neeg mob qog noj ntshav (CRC) cuam tshuam nrog CRC qog nqaij hlav thiab qhov kev ncua deb ntawm metastasis nrog rau theem kho mob siab dua.Qhov tseem ceeb, nce IFITM1 kev qhia yog ib qho kev ywj pheej prognostic yam rau kev ciaj sia tsis zoo.Txhawm rau tshawb xyuas cov txheej txheem molecular, peb tau pom tias kev tshaj tawm ntawm IFITM1 hauv CRC hlwb tau txhawb nqa, thaum lub sij hawm knockdown ntawm IFITM1 qhia inhibited, cell migration/invasion thiab tumorigenicity hauv vitro.Tsis tas li ntawd, peb tau txheeb xyuas Caveolin-1 (CAV1) raws li lub hom phiaj qis ntawm IFITM1-induced cell invasion, raws li knockdown ntawm CAV1 abrogated siIFITM1 mediated inhibition ntawm cell invasion hauv CRC hlwb.Tsis tas li ntawd, hauv CRC pawg ntawm 229 tus neeg mob, qhov kev qhia ntawm IFITM1 inversely correlated nrog kev qhia ntawm CAV1.Cov txiaj ntsig no tau qhia tias IFITM1 txhawb nqa qhov agr essiveness ntawm CRC hlwb, thiab nws yog lub peev xwm prognostic marker thiab kho lub hom phiaj rau CRC.
