Heparin sodium CAS: 9041-08-1 dawb los yog yuav luag dawb, hygroscopic hmoov
| Catalog Number | xwm 90184 |
| Khoom npe | Heparin sodium |
| CAS | 9 041-08-1 |
| Molecular Formula | C12H17NO20S3 |
| Molecular Luj | 591.45 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 30019091 ib |
Khoom Specification
| Qhov tshwm sim | dawb los yog yuav luag dawb, hygroscopic hmoov |
| Assay | 99% |
| Kev sib hloov tshwj xeeb | Cov khoom qhuav yuav tsum tsis pub tsawg tshaj +50 ° |
| pH | 5.5-8.0 Nws |
| Cov kab mob endotoxin | Tsawg dua 0.01 IU rau International Unit ntawm heparin |
| Residual kuab tshuaj | Raws li cov txheej txheem sab hauv nrog kev suav thaj tsam ncov, methanol, ethanol, acetone, thiab, tig, 0.3%, 0.5%, lossis tsawg dua |
| Residue ntawm Ignition | 28.0% -41.0% |
| Sodium | 10.5% -13.5% (cov khoom qhuav) |
| Protein | <0.5% (cov khoom qhuav) |
| Nitrogen | 1.3% -2.5% (cov khoom qhuav) |
| Nucleotidic impurities | 260nm <0.10 |
| Hnyav Hlau | ≤ 30ppm |
| Clarity thiab xim ntawm kev daws | Kev daws yuav tsum yog xim tsis muaj xim;Xws li turbidity, ultraviolet-pom spectrophotometric, kev txiav txim siab absorbance ntawm lub wavelength ntawm 640 nm, yuav tsum tsis txhob tshaj 0.018;Xws li xim, piv nrog cov qauv colorimetric kua daj, yuav tsum tsis txhob tob |
| Yam khoom | Cov txiaj ntsig ntawm dermatan sulfate thiab chondroitin sulphate: tsis ntau tshaj li ntawm aera ntawm lub ncov sib xws hauv chomatogram tau nrog kev siv tshuaj.Lwm yam impurity: tsis muaj peaks uas tsis yog lub ncov vim determatan sulfate thiab chondroitin sulfate raug kuaj pom. |
| anti-FXa / anti-FIIA | 0.9-1.1 |
| Ua kua chromatography | Kev tswj cov qauv kev daws teeb meem hauv chromatogram, dermatan sulfate (nce siab thiab heparin thiab dermatan sulfate) nruab nrab ntawm qhov siab ntawm qhov siab yuav tsum tsis pub tsawg dua 1.3, tau txais nrog cov tshuaj ntsuam xyuas zoo sib xws hauv lub sijhawm tuav thiab cov duab mus rau lub hauv paus ncov hauv chromatogram tau nrog siv kev daws teeb meem.Lub sijhawm khaws cia tus txheeb ze sib txawv yuav tsum tsis pub tshaj 5% |
| Molecular hnyav thiab molecular hnyav faib | Qhov hnyav nruab nrab molecular hnyav yuav tsum yog 15000 - 19000. Qhov hnyav molecular ntawm ntau dua 24000 ntawm qib yuav tsum tsis txhob ntau tshaj 20%, qhov hnyav molecular ntawm 8000 - 16000 ntawm qhov hnyav molecular ntawm 24000 - 16000 ntawm qhov piv yuav tsum tsis txhob tsawg dua. tshaj 1 |
| qhuav poob phaus | ≤ 5.0% |
| Cov kab mob microorganisms | Tag nrho cov suav aerobic: <10³cfu/g .Fungi/poov xab <10²cfu/g |
| anti-factor IIa | ≥180 IU/mg |
Heparin, Sodium ntsev yog heparin polymer uas ua rau nws cov nyhuv anticoagulant loj los ntawm kev ua kom muaj antithrombin.Qhov kev ua kom no ua rau muaj kev hloov pauv hauv ATIII thiab tso cai rau kev ua kom yooj yim dua hauv nws qhov chaw rov ua haujlwm.Heparin yog ib qho sulfated glycosaminoglycan uas paub txog kev tiv thaiv cov ntshav txhaws.Heparin, Sodium ntsev kuj yog ib qho activator ntawm RyR thiab ATIII.
Lub cev thiab tshuaj lom neeg: Heparin sodium yog dawb los yog yuav luag dawb hmoov, tsw ntxhiab, hygroscopic, soluble hauv dej, insoluble hauv organic solvents xws li ethanol thiab acetone.Nws muaj cov nqi tsis zoo hauv cov tshuaj aqueous thiab tuaj yeem ua ke nrog qee cov cations los tsim cov molecular complexes.Aqueous daws yog ruaj khov dua ntawm pH 7.
Anticoagulant: Heparin sodium yog ib qho tshuaj tiv thaiv coagulant, mucopolysaccharide, sodium ntsev ntawm glucosamine sulfate rho tawm los ntawm plab hnyuv mucosa ntawm npua, nyuj thiab yaj, thiab secreted los ntawm mast hlwb nyob rau hauv tib neeg lub cev.Thiab ib txwm muaj nyob hauv cov ntshav.Heparin sodium muaj lub luag haujlwm ntawm kev tiv thaiv platelet aggregation thiab kev puas tsuaj, inhibiting kev hloov ntawm fibrinogen rau hauv fibrin monomer, inhibiting tsim thromboplastin thiab tiv thaiv cov tsim thromboplastin, tiv thaiv kev hloov ntawm prothrombin rau thrombin thiab antithrombin.Heparin sodium tuaj yeem ncua lossis tiv thaiv cov ntshav coagulation ob leeg hauv vitro thiab hauv vivo.Nws cov txheej txheem ntawm kev ua haujlwm yog qhov nyuaj heev thiab cuam tshuam rau ntau qhov sib txuas hauv cov txheej txheem coagulation.Nws cov haujlwm yog: ① inhibit tsim thiab ua haujlwm ntawm thromboplastin, yog li tiv thaiv prothrombin los ntawm kev ua thrombin;② nyob rau hauv ntau dua, nws muaj cov nyhuv ntawm inhibiting thrombin thiab lwm yam coagulation yam, tiv thaiv fibrinogen los ua fibrin Protein;③ tuaj yeem tiv thaiv kev sib sau thiab kev puas tsuaj ntawm platelets.Tsis tas li ntawd, cov nyhuv anticoagulant ntawm heparin sodium tseem cuam tshuam rau qhov tsis zoo ntawm sulfate radical hauv nws cov molecule.Kev them nyiaj zoo alkaline xws li protamine lossis toluidine xiav tuaj yeem ua rau nws cov nqi tsis zoo, yog li nws tuaj yeem cuam tshuam nws cov tshuaj tiv thaiv.nyhuv.Vim tias heparin tuaj yeem qhib thiab tso tawm lipoprotein lipase hauv vivo, hydrolyze triglyceride thiab tsawg-density lipoprotein ntawm chylomicrons, yog li nws kuj muaj cov nyhuv hypolipidemic.Heparin sodium tuaj yeem siv los kho cov kab mob thromboembolic, tshaj tawm cov kab mob hauv lub cev (DIC).Hauv xyoo tas los no, heparin tau pom tias muaj cov txiaj ntsig ntawm kev tshem tawm cov ntshav lipids.Intravenous txhaj los yog tob intramuscular txhaj (los yog subcutaneous txhaj), 5,000 mus rau 10,000 units txhua zaus.Heparin sodium yog qhov tsis muaj tshuaj lom thiab tsis muaj ntshav txaus yog qhov tseem ceeb tshaj plaws ntawm heparin overdose.Kev hais lus tsis zoo, nws yuav tsum tau txhaj tshuaj.Kev txhaj tshuaj intramuscular lossis txhaj tshuaj subcutaneous yog qhov khaus ntau dua, qee zaus kev tsis haum tshuaj yuav tshwm sim, thiab kev siv tshuaj ntau dhau tuaj yeem ua rau mob plawv;qee zaus cov plaub hau poob thiab raws plab.Tsis tas li ntawd, nws tseem tuaj yeem ua rau pob txha tawg.Kev siv sijhawm ntev tuaj yeem ua rau mob thrombosis, uas tej zaum yuav yog qhov tshwm sim ntawm anticoagulase-III depletion.Heparin sodium yog contraindicated nyob rau hauv cov neeg mob uas los ntshav, mob siab heev thiab lub raum tsis ua hauj lwm, hnyav kub siab, hemophilia, intracranial hemorrhage, peptic ulcer, cev xeeb tub thiab postpartum, visceral hlav, raug mob thiab phais.
Siv: Kev tshawb fawb biochemical, siv los tiv thaiv kev hloov pauv ntawm prothrombin rau hauv thrombin, nrog cov nyhuv antithrombotic.
Siv: Heparin sodium yog mucopolysaccharide biochemical tshuaj muab rho tawm los ntawm porcine plab hnyuv mucosa nrog muaj zog anticoagulant.Mclcan nrhiav pom femoral mucopolysaccharide heparin hauv daim siab cov ntaub so ntswg los ntawm cov dev thaum kawm txog cov txheej txheem ntawm cov ntshav txhaws.Brinkous et al.ua pov thawj tias heparin muaj cov tshuaj tiv thaiv coagulant.Tom qab heparin tau siv los ua cov tshuaj tiv thaiv coagulant hauv kev kho mob thawj zaug, nws tau txais kev saib xyuas los ntawm thoob plaws lub ntiaj teb.Txawm hais tias nws muaj keeb kwm ntau dua 60 xyoo hauv kev siv tshuaj kho mob, tsis muaj cov khoom lag luam uas tuaj yeem hloov pauv tau tam sim no, yog li nws tseem yog ib qho tseem ceeb tshaj plaws anticoagulant thiab antithrombotic biochemical tshuaj.Nws muaj ntau hom kev siv tshuaj.Nws yog siv los kho mob myocardial infarction thiab pathogenic kab mob siab.Nws tuaj yeem siv ua ke nrog ribonucleic acid txhawm rau txhim kho kev ua haujlwm ntawm kab mob siab B. Nws tuaj yeem siv nrog kev siv tshuaj kho mob los tiv thaiv thrombosis.Nws tuaj yeem txo cov ntshav lipids thiab txhim kho tib neeg kev tiv thaiv kab mob.kuj muaj tej yam tshwm sim.Tsawg molecular hnyav heparin sodium muaj anticoagulant yam Xa kev ua haujlwm.Cov kev tshawb fawb Pharmacodynamic tau qhia tias qhov hnyav molecular hnyav heparin sodium muaj qhov cuam tshuam rau kev tsim cov thrombus thiab arteriovenous thrombosis hauv vivo thiab hauv vitro, tab sis tsis tshua muaj txiaj ntsig ntawm coagulation thiab fibrinolysis system, uas ua rau muaj cov nyhuv antithrombotic.los ntshav tsawg dua.Unfractionated heparin yog sib xyaw ntawm ntau yam amino glucan glycosides uas tuaj yeem ncua lossis tiv thaiv cov ntshav coagulation ob leeg hauv vitro thiab hauv vivo.Nws cov txheej txheem anticoagulation yog complex, thiab nws muaj kev cuam tshuam rau txhua yam ntawm coagulation.Nrog rau inhibition ntawm prothrombin rau hauv thrombin;inhibition ntawm thrombin kev ua haujlwm;cuam tshuam kev hloov pauv ntawm fibrinogen rau hauv fibrin;tiv thaiv platelet aggregation thiab kev puas tsuaj.Heparin tseem tuaj yeem txo cov ntshav lipids, txo qis LDL thiab VLDL, nce HDL, hloov ntshav viscosity, tiv thaiv vascular endothelial hlwb, tiv thaiv atherosclerosis, txhawb cov ntshav khiav, thiab txhim kho cov hlab ntsha.
Siv: Kev tshawb fawb biochemical, los tiv thaiv kev hloov pauv ntawm prothrombin rau hauv thrombin.
Siv: Siv los ncua thiab tiv thaiv cov ntshav txhaws
