Cov khoom

Ob peb guanosine analogues, piv txwv li acyclovir (thiab nws qhov ncauj prodrug valaciclovir), penciclovir (nyob rau hauv nws qhov ncauj prodrug daim ntawv, famciclovir) thiab ganciclovir, yog lug siv rau kev kho mob ntawm herpesvirus [xws li herpes simplex virus type 1 (HSV-1), thiab hom. 2 (HSV-2), varicella-zoster virus (VZV) thiab/los yog human cytomegalovirus (HCMV)] kab mob.Nyob rau hauv xyoo tas los no, ntau yam tshiab guanosine analogues tau tsim, suav nrog 3-tus tswvcuab cyclopropylmethyl thiab -methenyl derivatives (A-5021 thiab synguanol) thiab 6-tus tswvcuab D- thiab L-cyclohexenyl derivatives.Cov kev ua ntawm acyclic / carbocyclic guanosine analogues tau txiav txim siab tawm tsam ntau yam kab mob, suav nrog HSV-1, HSV-2, VZV, HCMV, thiab tib neeg herpesviruses hom 6 (HHV-6), hom 7 (HHV- 7) thiab hom 8 (HHV-8), thiab kab mob siab B (HBV).Cov guanosine analogues tshiab (xws li A-5021 thiab D- thiab L-cyclohexenyl G) tau pom tias muaj zog tshwj xeeb tiv thaiv cov kab mob (HSV-1, HSV-2, VZV) uas encode rau ib qho tshwj xeeb thymidine kinase (TK), tawm tswv yim. tias lawv cov tshuaj tiv thaiv kab mob (tsawg kawg ib nrab) nyob ntawm phosphorylation los ntawm tus kab mob TK.Cov tshuaj tiv thaiv kab mob kuj tau sau tseg nrog A-5021 tiv thaiv HHV-6 thiab nrog D- thiab L-cyclohexenyl G tiv thaiv HCMV thiab HBV.Cov tshuaj tiv thaiv kab mob ntawm acyclic / carbocyclic nucleoside analogues tuaj yeem ua rau muaj zog los ntawm mycophenolic acid, muaj zog inhibitor ntawm inosine 5'-monophosphate (IMP) dehydrogenase.Cov tshiab carbocyclic guanosine analogues (xws li A-5021 thiab D- thiab L-cyclohexenyl G) tuav cov lus cog tseg zoo, tsis yog tsuas yog cov tshuaj tiv thaiv kab mob rau kev kho mob ntawm tus kab mob herpesvirus, tab sis kuj muaj cov tshuaj tiv thaiv kab mob rau kev kho noob caj noob ces / tshuaj kho mob qog noj ntshav, muab tias (ib feem ntawm) cov qog hlwb tau hloov los ntawm tus kab mob (HSV-1, VZV) TK gene.