Glutathione oxidized Cas: 27025-41-8 Dawb crystalline hmoov
| Catalog Number | xwm 90283 |
| Khoom npe | Glutathione oxidized |
| CAS | 27025-41-8 |
| Molecular Formula | C20H32N6O12S2 |
| Molecular Luj | 612.63 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 2930909899 ib |
Khoom Specification
| Assay | 99% |
| Qhov tshwm sim | Dawb crystalline hmoov |
| Kev sib hloov tshwj xeeb | -96-106 |
| Cov hlau hnyav | 10 ppm max |
| AS | 2 ppm max |
| Poob rau ziab | 15.0% max. |
| Purity | 95% min |
| Residue ntawm Ignition | 0.5% max |
Hepatotoxicity ntawm cov neeg sib tw tshuaj yog ib qho kev txhawj xeeb loj hauv kev tshuaj xyuas tshuaj hauv kev tshawb nrhiav tshuaj thaum ntxov.Kev tshawb pom ntawm hepatic oxidative kev nyuaj siab tuaj yeem yog qhov taw qhia ntxov ntawm hepatotoxicity thiab cov txiaj ntsig kev xaiv tshuaj.Cov glutathione (GSH) thiab glutathione disulfide (GSSG) khub, uas yog ib qho ntawm cov kev sib koom ua ke loj hauv lub cev redox tswj cov khub niam txiv, ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv cov hlwb los ntawm kev ntxhov siab oxidative uas tshwm sim los ntawm kev tsis sib xws ntawm prooxidants thiab antioxidants.Kev txiav txim siab ntau ntawm GSSG / GSH ratios thiab cov concentrations ntawm GSH thiab GSSG tau siv los qhia oxidative kev nyuaj siab hauv hlwb thiab cov ntaub so ntswg.Hauv txoj kev tshawb no, peb tau sim qhov muaj peev xwm ntawm kev siv cov biliary GSSG / GSH ratios raws li biomarker los cuam tshuam cov kab mob siab oxidative kev nyuaj siab thiab tshuaj toxicity.Plaub lub tebchaw uas paub tias hloov GSH thiab GSSG qib tau sim hauv txoj kev tshawb no.Diquat (diquat dibromide monohydrate) thiab acetaminophen tau muab rau nas.Paraquat thiab tert-butyl hydroperoxide tau muab d rau cov nas kom ua rau muaj kev hloov pauv ntawm biliary GSH thiab GSSG.Cov biliary GSH thiab GSSG tau suav hais tias siv calibration curves npaj nrog cov kua tsib kom suav nrog cov kua tsib matrix hauv LC-MS tsom xam thiab kom tsis txhob cuam tshuam ntawm endogenous GSH thiab GSSG.Nrog plaub tus piv txwv (hauv nas thiab nas) ntawm cov tshuaj-vim cov kev hloov pauv hauv cov kinetics ntawm biliary GSSG / GSH ratios, qhov kev tshawb fawb no tau pom tias muaj peev xwm los tsim qhov kev cuam tshuam qhov tshwm sim raws li biliary GSSG / GSH piv rau kev kwv yees kab mob siab oxidative kev nyuaj siab.
