Gentamycin Sulfate CAS: 1405-41-0 Dawb hmoov
| Catalog Number | xwm 90364 |
| Khoom npe | Gentamycin Sulfate |
| CAS | 1405-41-0 |
| Molecular Formula | C21H43N5O7H2So4 |
| Molecular Luj | 575.68 ib |
| Cov ntaub ntawv khaws cia | 2 txog 8 ° C |
| Harmonized tariff Code | 29419000 ib |
Khoom Specification
| Dej | 15% max |
| pH | 3.5-5.5 |
| Assay | 590 IU/mg min |
| Kev sib hloov tshwj xeeb | +107 ° txog +121 ° |
| Qhov tshwm sim | Dawb hmoov |
| Sulfate (SO4) | 32-35% |
| Sulfated tshauv | <1.0% |
Contusive tus txha caj qaum raug mob yog qhov nyuaj los ntawm ncua sij hawm poob ntawm oligodendrocytes, uas ua rau muaj mob demyelination.Yog li ntawd, cov tswv yim hloov pauv los muab cov kab mob oligodendrocyte thiab txhim kho qhov loj ntawm myelination tshwm sim tau tsim nyog rau kev kho tus txha caj qaum.Txoj kev tshawb fawb tam sim no tau tshawb xyuas seb kev hloov pauv ntawm tib neeg cov kab mob neural qia hlwb (NSCs) hloov pauv hloov pauv los qhia txog Olig2 qhov kev hloov pauv, qhov tseem ceeb ntawm kev txhim kho oligodendrocyte, tuaj yeem txhim kho locomotor rov qab los thiab txhim kho myelination hauv cov nas kis kab mob qaum qaum qauv.HB1.F3 (F3). ) immortalized tib neeg NSC kab tau hloov pauv nrog ib qho kev hloov pauv vector encoding Olig2, qhov tseem ceeb ntawm kev txhim kho oligodendrocyte.Overexpression ntawm Olig2 nyob rau hauv tib neeg NSCs (F3.Olig2) induced activation ntawm NKX2.2 thiab qhia txawv NSCs rau hauv oligodendrocyte kab mob hlwb hauv vitro.Kev Taw Qhia ntawm Olig2 tau tshaj tawm cov kev ua ub no ntau dua, thiab ntau tus lej ntawm F3.Olig2 NSCs tau kuaj pom los ntawm 7 lub lis piam tom qab hloov pauv mus rau hauv tus txha caj qaum dua li ntawm niam txiv F3 NSCs.F3.Olig2 NSCs tau nthuav tawm nquag tsiv teb tsaws ntawm cov teeb meem dawb, qhov F3 NSCs feem ntau raug kaw rau cov teeb meem grey lossis ib ncig ntawm cov kab noj hniav.Feem ntau ntawm F3.Olig2 NSCs nyob hauv qhov chaw dawb dawb sib txawv rau hauv cov laus oligodendrocytes.Kev hloov pauv ntawm F3.Olig2 NSCs nce qhov ntim ntawm cov khoom dawb dawb thiab txo cov kab noj hniav.Ntxiv mus, F3.Olig2 grafts ho nce lub thickness ntawm myelin sheath nyob ib ncig ntawm lub axons nyob rau hauv lub spared dawb teeb meem.Thaum kawg, tsiaj txhu nrog F3.Olig2 grafts pom kev txhim kho hauv qhov zoo ntawm hindlimbs locomotion.Transplantation ntawm NSCs genetically hloov kho kom sib txawv rau hauv cov kab mob oligodendrocytic tej zaum yuav yog ib lub tswv yim zoo los txhim kho cov txiaj ntsig ua haujlwm tom qab kev raug mob qaum qaum.Txoj kev tshawb fawb tam sim no qhia tias cov yam ntxwv molecular tswj kev txiav txim siab txoj hmoo ntawm tes tuaj yeem siv los ua kom muaj peev xwm kho tau ntawm kev kho ntawm tes.
